ALOX5
arachidonate 5-lipoxygenase
别名:
5-LO, 5-LOX, 5LPG, LOG5
物种:
Human ALOX5 (240), Mouse Alox5 (11689), Rat Alox5 (25290), sheep ALOX5 (101117390), naked mole-rat Alox5 (101700210), Zebrafish alox5 (573013), Zebrafish alox5 (567204), chicken ALOX5 (423769), dog ALOX5 (477753), cow ALOX5 (404074) ...展开
UniProtKB ID:
基因ID:
- Human(240) Summary: This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
- Mouse(11689) arachidonate 5-lipoxygenase
- Rat(25290) arachidonate 5-lipoxygenase
- sheep(101117390) arachidonate 5-lipoxygenase
- naked mole-rat(101700210) arachidonate 5-lipoxygenase
- Zebrafish(573013) arachidonate 5-lipoxygenase
- Zebrafish(567204) arachidonate 5-lipoxygenase
- chicken(423769) arachidonate 5-lipoxygenase
- dog(477753) arachidonate 5-lipoxygenase
- cow(404074) arachidonate 5-lipoxygenase
- domestic cat(101097422) arachidonate 5-lipoxygenase
- Horse(100062042) arachidonate 5-lipoxygenase
- domestic guinea pig(100718093) arachidonate 5-lipoxygenase
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
货号
说明
物种反应性
应用
Anti-ALOX5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-ALOX5 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
物种反应性
human, mouse
应用
immunofluorescence
western blot
western blot
Anti-5′-Lipoxygenase Antibody, Chemicon®, from rabbit,
物种反应性
human, mouse, rabbit, rat
应用
ELISA
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-Arachidonate 5 Lipoxygenase antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot