InChI key
DXDRHHKMWQZJHT-FPYGCLRLSA-N
SMILES string
Oc1ccc(cc1)\C=C\C(=O)c2ccc(O)cc2O
InChI
1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+
form
powder
color
yellow to orange
solubility
H2O: <0.1 mg/mL, methanol: 10 mg/mL, DMSO: 20 mg/mL
storage temp.
2-8°C
Quality Level
Gene Information
rat ... Alox5(25290)
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General description
异甘草素是一种芳香族酮,属于查耳酮化合物类。它来源于甘草,是药品和食品中的一种成分。
Application
异甘草素已被用于:
- 作为斑马鱼胚胎中的骨形态发生蛋白(BMP)激动剂
- 作为斑马鱼胚胎中的鸟苷酸环化酶激活剂
- 用于测试其对Epstein-Barr病毒相关胃癌的抗肿瘤和抗病毒作用
Biochem/physiol Actions
异甘草素是一种可溶性鸟苷酸环化酶激活剂,具有抗肿瘤活性。它还具有抗氧化、抗血小板和雌激素特性。
Features and Benefits
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
Disclaimer
光敏性、吸湿性
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Vasorelaxant effect of isoliquiritigenin, a novel soluble guanylate cyclase activator, in rat aorta.
S M Yu et al.
British journal of pharmacology, 114(8), 1587-1594 (1995-04-01)
1. The vasorelaxant activity of isoliquiritigenin, isolated from Dalbergia odorifera T, was investigated in the phenylephrine-precontracted rat aorta by measuring tension, guanylate and adenylate cyclase activities, guanosine 3':5'-cyclic monophosphate (cyclic GMP) and adenosine 3':5'-cyclic monophosphate (cyclic AMP) levels. 2. Isoliquiritigenin
Small molecule modifier screen for kit-dependent functions in zebrafish embryonic melanocytes
Hultman KA, et al.
Zebrafish, 5(4), 279-287 (2008)
Suengmok Cho et al.
Biochemical and biophysical research communications, 413(4), 637-642 (2011-09-29)
Isoliquiritigenin (ILTG) is a chalcone compound and has valuable pharmacological properties such as antioxidant, anti-inflammatory, anticancer, and antiallergic activities. Recently, the anxiolytic effect of ILTG has been reported; however, its action mechanism and hypnotic activity have not yet been demonstrated.
Isoliquiritigenin regulates the circ_0002860/miR-431-5p/RAB9A axis to function as a tumor inhibitor in melanoma.
Wu, et al.
Journal of Venomous Animals and Toxins including Tropical Diseases, 29, e20220019-e20220019 (2023)
Xuan Yuan et al.
Recent patents on anti-cancer drug discovery, 8(2), 191-199 (2012-09-12)
Isoliquiritigenin (ISL), a licorice chalconoid, is a bioactive agent with chemopreventive potential that has been patented for tumor treatment in China. This study investigated the mechanisms of ISL-induced apoptosis in ovarian carcinoma SKOV-3 cells. Cell viability was evaluated using a
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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