所有图片(1)
About This Item
经验公式（希尔记法）:
C15H12O4
CAS号:
分子量:
256.25
Beilstein:
1914296
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
表单
powder
质量水平
颜色
yellow to orange
溶解性
H2O: <0.1 mg/mL
methanol: 10 mg/mL
DMSO: 20 mg/mL
储存温度
2-8°C
SMILES字符串
Oc1ccc(cc1)\C=C\C(=O)c2ccc(O)cc2O
InChI
1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+
InChI key
DXDRHHKMWQZJHT-FPYGCLRLSA-N
基因信息
rat ... Alox5(25290)
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一般描述
异甘草素是一种芳香族酮，属于查耳酮化合物类。它来源于甘草，是药品和食品中的一种成分。
应用
异甘草素已被用于：
- 作为斑马鱼胚胎中的骨形态发生蛋白（BMP）激动剂
- 作为斑马鱼胚胎中的鸟苷酸环化酶激活剂
- 用于测试其对Epstein-Barr病毒相关胃癌的抗肿瘤和抗病毒作用
生化/生理作用
异甘草素是一种可溶性鸟苷酸环化酶激活剂，具有抗肿瘤活性。它还具有抗氧化、抗血小板和雌激素特性。
特点和优势
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
注意
光敏性、吸湿性
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Suengmok Cho et al.
Biochemical and biophysical research communications, 413(4), 637-642 (2011-09-29)
Isoliquiritigenin (ILTG) is a chalcone compound and has valuable pharmacological properties such as antioxidant, anti-inflammatory, anticancer, and antiallergic activities. Recently, the anxiolytic effect of ILTG has been reported; however, its action mechanism and hypnotic activity have not yet been demonstrated.
Gang Chen et al.
Apoptosis : an international journal on programmed cell death, 17(1), 90-101 (2011-10-01)
Previous studies, including those from our laboratory, have demonstrated that isoliquiritigenin (ISL), a flavonoid isolated from licorice, is a promising cancer chemotherapeutic agent. However the mechanisms underlying its anticancer effects are still far from clear. We now show, for the
Quercetin-induced apoptosis prevents EBV infection
Lee M, et al.
Testing, 6(14), 12603-12603 (2015)
Isoliquiritigenin regulates the circ_0002860/miR-431-5p/RAB9A axis to function as a tumor inhibitor in melanoma.
Wu, et al.
Journal of Venomous Animals and Toxins including Tropical Diseases, 29, e20220019-e20220019 (2023)
Vasorelaxant effect of isoliquiritigenin, a novel soluble guanylate cyclase activator, in rat aorta.
S M Yu et al.
British journal of pharmacology, 114(8), 1587-1594 (1995-04-01)
1. The vasorelaxant activity of isoliquiritigenin, isolated from Dalbergia odorifera T, was investigated in the phenylephrine-precontracted rat aorta by measuring tension, guanylate and adenylate cyclase activities, guanosine 3':5'-cyclic monophosphate (cyclic GMP) and adenosine 3':5'-cyclic monophosphate (cyclic AMP) levels. 2. Isoliquiritigenin
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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