¥4,472.02
国内现货，预计发货时间2025年4月27日详情
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产品名称
抗 MAP2 兔抗, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~280 kDa
antigen ~72 kDa
种属反应性
rat, mouse, human
1 of 4
此商品 | HPA012558 | HPA012828 | HPA008273 |
|---|---|---|---|
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| antibody form affinity isolated antibody | antibody form affinity isolated antibody | antibody form affinity isolated antibody | antibody form affinity isolated antibody |
| biological source rabbit | biological source rabbit | biological source rabbit | biological source rabbit |
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| mol wt antigen ~280 kDa, antigen ~72 kDa | mol wt - | mol wt - | mol wt - |
| clone polyclonal | clone polyclonal | clone polyclonal | clone polyclonal |
一般描述
MAP2 是一种与微管相关的蛋白，调节细胞骨架的结构和功能。该蛋白也调节神经元的形态发生和细胞增殖。MAP2和F-actin的相互作用与神经突初生（neurite initiation）和微管再组装有关。MAP2 的水平下降与传染性海绵状脑病相关[1]。抗MAP2抗体对于人、小鼠和大鼠MAP2有特异性。
微管相关蛋白 2 (Microtubule associated protein 2，MAP2) 是一种神经元特异性蛋白，在中枢神经系统中广泛表达。它是细胞骨架蛋白中的一员。 该基因位于人类染色体 2q34 上。
免疫原
相应的人 MAP2 残基 2-15 的合成肽。
应用
兔抗 MAP2 抗体可用于免疫细胞化学。
抗 MAP2 抗体适用于免疫组织化学（1:500，使用 Zamboni 固定剂固定、冷冻的小鼠脊髓和丘脑切片）、流式细胞术 (1:200-1:500)、免疫印迹（约 72 kDa 和 280 kDa）和蛋白质印迹 (1:500-1:1,000)。
生化/生理作用
微管相关蛋白2（MAP2）在星形胶质细胞和少突胶质细胞中树突状突起的形成过程中起关键作用。它可以维持微管的稳态。该蛋白在神经可塑性中起重要作用。
外形
溶剂为含有0.02％叠氮化钠的磷酸盐缓冲盐水。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
Specific binding of dehydroepiandrosterone to the N terminus of the microtubule-associated protein MAP2
Laurine E, et al.
The Journal of Biological Chemistry, 278(32), 29979-29986 (2003)
Cory C Toth et al.
Molecular pain, 6, 16-16 (2010-03-20)
Despite the frequency of diabetes mellitus and its relationship to diabetic peripheral neuropathy (DPN) and neuropathic pain (NeP), our understanding of underlying mechanisms leading to chronic pain in diabetes remains poor. Recent evidence has demonstated a prominent role of microglial
Transcriptional upregulation of microtubule-associated protein 2 is involved in the protein kinase A-induced decrease in the invasiveness of glioma cells
Zhou Y, et al.
Neuro-Oncology, 17(12), 1578-1588 (2015)
Involvement of microtubule-associated protein 2 (MAP2) in oral cancer cell motility: a novel biological function of MAP2 in non-neuronal cells
Liu SY, et al.
Biochemical and Biophysical Research Communications, 366(2), 520-525 (2008)
Bogdan A Stoica et al.
Journal of neurotrauma, 31(8), 758-772 (2014-01-31)
Traumatic brain injury (TBI) causes neuronal cell death as well as microglial activation and related neurotoxicity that contribute to subsequent neurological dysfunction. Poly (ADP-ribose) polymerase (PARP-1) induces neuronal cell death through activation of caspase-independent mechanisms, including release of apoptosis inducing
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