所有图片(4)
别名:
NMDA, （R）-2-（甲氨基）琥珀酸
经验公式（希尔记法）:
C5H9NO4
CAS号:
分子量:
147.13
Beilstein:
1724431
MDL编号:
UNSPSC代码:
12352209
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.32
推荐产品
质量水平
检测方案
≥98% (TLC)
形式
solid
技术
cell culture | mammalian: suitable
颜色
white
mp
189-190 °C
应用
cell analysis
SMILES字符串
CN[C@H](CC(O)=O)C(O)=O
InChI
1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1
InChI key
HOKKHZGPKSLGJE-GSVOUGTGSA-N
基因信息
human ... GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRINA(2907)
rat ... Gria1(50592) , Grik1(29559) , Grin2a(24409)
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一般描述
N-甲基-D-天冬氨酸（NMDA）是大鼠神经系统和内分泌腺中的内生分子。NMDA在腺垂体、下丘脑、脑和睾丸中以低水平（nmol/g）存在。NMDA通过S-腺苷甲硫氨酸依赖性酶（也称为NMDA合酶）对D-Asp衍生而来。
应用
N-甲基-D-天冬氨酸已用于诱导N-甲基-d-天冬氨酸（NMDA）的毒性，视网膜细胞培养物补充有NMDA。
生化/生理作用
N-甲基-D-天冬氨酸（NMDA）对于垂体中促黄体激素和PRL（催乳素），以及下丘脑中的GnRH（促性腺激素释放激素）的释放起着关键作用。它可作为NMDA型谷氨酸受体的特异性激动剂。
兴奋毒性氨基酸。NMDA型谷氨酸受体的原型激动剂，可调节离子通道；在长时程增强、缺血和癫痫中起重要作用。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Calpain- and caspase-mediated aII-spectrin
and tau proteolysis in rat cerebrocortical
neuronal cultures after ecstasy or
methamphetamine exposure.
and tau proteolysis in rat cerebrocortical
neuronal cultures after ecstasy or
methamphetamine exposure.
Warren MW
The International Journal of Neuropsychopharmacology, 9, 1-11 (2006)
Occurrence of D-aspartic acid and N-methyl-D-aspartic acid in rat neuroendocrine tissues and their role in the modulation of luteinizing hormone and growth hormone release.
D'Aniello A
Faseb Journal, 14(5), 699-714 (2000)
Juan Ding et al.
Neural regeneration research, 14(12), 2112-2117 (2019-08-10)
N-methyl-D-aspartate receptor hypofunction is the basis of pathophysiology in schizophrenia. Blocking the N-methyl-D-aspartate receptor impairs learning and memory abilities and induces pathological changes in the brain. Previous studies have paid little attention to the role of the N-methyl-D-aspartate receptor subunit
N-methyl-D-aspartic acid (NMDA) in the nervous system of the amphioxus Branchiostoma lanceolatum.
D'Aniello S
BMC Neuroscience, 8:109 (2007)
Guendalina Olivero et al.
Molecular neurobiology, 56(9), 6142-6155 (2019-02-09)
Mouse hippocampal glutamatergic nerve endings express presynaptic release-regulating NMDA autoreceptors (NMDARs). The presence of GluN1, GluN2A, GluN2B, and GluN3A subunits in hippocampal vesicular glutamate transporter type 1-positive synaptosomes was confirmed with confocal microscopy. GluN2C, GluN2D, and GluN3B immunopositivity was scarcely
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