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安全信息

M109

Sigma-Aldrich

2-Methylserotonin maleate salt

≥98% (HPLC)

别名:

2-Methyl-5-hydroxytryptamine maleate salt, 3-(2-Aminoethyl)-2-methyl-1H-indol-5-ol maleate salt

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About This Item

经验公式（希尔记法）:
C11H14N2O · C4H4O4
CAS号:
78263-91-9
分子量:
306.31
MDL编号:
MFCD00082467
UNSPSC代码:
12352200
PubChem化学物质编号:
24278101

方案

≥98% (HPLC)

表单

solid

颜色

tan

溶解性

H2O: 4.5 mg/mL

储存温度

−20°C

SMILES字符串

OC(=O)\C=C/C(O)=O.Cc1[nH]c2ccc(O)cc2c1CCN

基因信息

human ... HTR3A(3359) , HTR3B(9177)

生化/生理作用

5-HT3 serotonin receptor agonist.

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
048K4614
056K4622
127H4734

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T Endo et al.
Research communications in molecular pathology and pharmacology, 104(2), 145-155 (2000-01-14)
The object of this study was to evaluate the involvement of 5-HT3 receptors in the regulation of 5-HT release from the small intestine using ferrets, an animal model of emesis. 2-Methyl-5-HT, a 5-HT3 receptor agonist, produced a concentration-dependent increase of
D M Gillies et al.
European journal of pharmacology, 303(1-2), 1-12 (1996-05-06)
5-Hydroxytryptamine (5-HT) is involved in the modulation of dopaminergic activity in the mesolimbic system, but its sites of action and the receptors involved are not well understood. Locomotor activity responses in rats were monitored in Animex automated activity boxes following
A M Ismaiel et al.
Journal of medicinal chemistry, 33(2), 755-758 (1990-02-01)
alpha-Methyl-5-hydroxytryptamine (alpha-Me-5-HT; 2) and 2-methyl-5-hydroxytryptamine (2-Me-5-HT; 3) are considered to be 5-HT2-selective and 5-HT3-selective agents, respectively. These agents were synthesized and examined at serotonin (5-HT) binding sites because there is relatively little documentation as to their selectivity and because they
Weixia Zhong et al.
PloS one, 9(8), e104718-e104718 (2014-08-15)
Stimulation of 5-HT3 receptors (5-HT3Rs) by 2-methylserotonin (2-Me-5-HT), a selective 5-HT3 receptor agonist, can induce vomiting. However, downstream signaling pathways for the induced emesis remain unknown. The 5-HT3R channel has high permeability to extracellular calcium (Ca(2+)) and upon stimulation allows

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