所有图片(4)
别名:
2-(4-异丁苯)丙酸, Motrin, Rebugen, 布洛芬, α-甲基-4-(异丁基)苯乙酸, (±)-2-(4-异丁基苯基)丙酸
经验公式（希尔记法）:
C13H18O2
CAS号:
分子量:
206.28
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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生物来源
synthetic (organic)
质量水平
检测方案
≥98% (GC)
形式
powder
mp
77-78 °C
溶解性
ethanol: 50 mg/mL, clear, colorless to faintly yellow
SMILES字符串
CC(C)Cc1ccc(cc1)C(C)C(O)=O
InChI
1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
InChI key
HEFNNWSXXWATRW-UHFFFAOYSA-N
基因信息
human ... ALB(213) , ALOX5(240) , CYP1A2(1544) , CYP2C9(1559) , IL8RA(3577) , PTGS1(5742) , PTGS2(5743)
mouse ... Alox5(11689)
rat ... Alox5(25290) , Ptgs1(24693)
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一般描述
布洛芬是一种非类固醇抗炎药(NSAID)，常用来止痛、消炎、退烧。它会抑制多种抗高血压药物作用，包括β肾上腺素能阻滞剂、血管紧张素转换酶抑制剂、血管紧张素受体阻滞剂和利尿剂。布洛芬在脑脊液中以未结合状态存在，在关节炎患者中会积聚在炎症关节的滑膜液中。
应用
布洛芬用于：
- 研究其对新生儿肺发育的血管和肺影响
- 研究其对人胆管癌细胞株凋亡、增殖和组织学变化的影响
- 在萜类治疗性低共溶体系(therapeutic deep eutectic system)制备中，研究其物化、抗菌和抗癌特性。
生化/生理作用
环加氧酶 (COX) 抑制剂，对 COX-1 的抑制活性大于对 COX-2 的抑制活性。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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