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G8168

G418 disulfate salt

solution, non-animal origin, suitable for cell culture, BioReagent

别名:

抗生素G418

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关于此项目

经验公式（希尔记法）:
C20H40N4O10 · 2H2SO4
化学文摘社编号:
108321-42-2
分子量:
692.71
MDL number:
MFCD00058314
UNSPSC Code:
12352207
PubChem Substance ID:
24895333
NACRES:
NA.76
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产品名称

G 418 二硫酸盐 溶液, 50 mg/mL in H2O, 0.1 μm filtered, BioReagent, suitable for cell culture

biological source

Micromonospora echinospora

Quality Level

200

sterility

0.1 μm filtered

product line

BioReagent

form

solution

potency

50-60 mg per mL

mol wt

692.7

packaging

pkg of 10 and 100 mL

concentration

50 mg/mL in H2O

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

colorless

solubility

H2O: 50 mg/mL, clear

antibiotic activity spectrum

parasites

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

OS(O)(=O)=O.OS(O)(=O)=O.CN[C@H]1[C@H](O)[C@@H](OC[C@@]1(C)O)O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H]([C@H](C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O

InChI

1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;2*1-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2*(H2,1,2,3,4)/t6?,7-,8+,9+,10+,11-,12-,13-,14+,15+,16-,17-,18+,19-,20+;;/m0../s1

InChI key

UHEPSJJJMTWUCP-NKCAIAFTSA-N

General description

化学结构：氨基糖苷类

Application

G418二硫酸盐是一种氨基糖苷类抗生素，其结构与庆大霉素相似，用于选择和维持原核和真核细胞。不同细胞系具有不同的筛选和维持最佳浓度。 细菌和藻类最多需要5 μg/mL而动物细胞则可能需要300-500 μg/mL。

Biochem/physiol Actions

作用机制：G418可通过抑制70S和80S核糖体的合成来阻止多肽合成和蛋白质延伸。

抗菌谱：G418可选择经iNOS启动子构建体和新霉素抗性基因稳定转染的细胞，并显示出对原生动物和蠕虫的活性。

Disclaimer

该产品在2-8°C下可稳定储存两年。

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pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

存储类别

12 - Non Combustible Liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000502639
0000502641
0000502639
0000502641
0000406785

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实验方案

CRISPR Lentiviral Screening: Antibiotic Selection

Lentivirus versions of genome modification technologies support successful CRISPR, RNAi, and ORF experiments.

FACS Titration of Lentivirus Protocol

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Safe Lentivirus Handling

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Successful Transduction Using Lentivirus

Get tips for handling lentiviruses, optimizing experiment setup, titering lentivirus particles, and selecting helpful products for transduction.

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全球贸易项目编号

货号GTIN
G8168-100ML04061838447203
G8168-10ML04061838447227