E1896
Etazolate hydrochloride
solid
别名:
1-Ethyl-4-[(1-methylethylidene)hydrazino]1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester hydrochloride, SQ 20009
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关于此项目
经验公式（希尔记法）:
C14H18N5O2 · HCl
化学文摘社编号:
分子量:
324.79
UNSPSC Code:
41106305
PubChem Substance ID:
MDL number:
InChI
1S/C14H19N5O2.ClH/c1-5-19-13-10(8-16-19)12(18-17-9(3)4)11(7-15-13)14(20)21-6-2;/h7-8H,5-6H2,1-4H3,(H,15,18);1H
SMILES string
Cl.CCOC(=O)c1cnc2n(CC)ncc2c1N\N=C(\C)C
InChI key
GQJUGJHJUZSJLZ-UHFFFAOYSA-N
assay
≥98% (TLC)
form
solid
color
white
mp
193-194 °C
solubility
H2O: >20 mg/mL (Solutions should be freshly prepared.)
storage temp.
room temp
Gene Information
human ... GABRB3(2562), PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
Biochem/physiol Actions
Selective inhibitor of cAMP-specific phosphodiesterase.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Jason Drott et al.
European journal of pharmacology, 634(1-3), 95-100 (2010-03-13)
Etazolate is a phosphodiesterase 4 (PDE4) inhibitor and GABAA receptor modulator that also stimulates alpha-secretase activity and neurotrophic soluble amyloid precursor protein (sAPPalpha) production, currently developed as a possible Alzheimer's disease therapeutic. In this study two doses of etazolate were
P L Wood et al.
The Journal of pharmacology and experimental therapeutics, 231(3), 572-576 (1984-12-01)
Using an extensively washed membrane preparation and standardized incubation conditions, the actions of benzodiazepine (BZ) receptor ligands were evaluated on [3H]flunitrazepam [+/- 10 microM gamma-aminobutyric acid (GABA)], [3H]muscimol (+/- 2.5 microM etazolate) and [35S]butyl bicyclophosphorothionate (TBPS) binding. Classical BZ receptor
Anxioselective anxiolytics.
M Williams
Journal of medicinal chemistry, 26(5), 619-628 (1983-05-01)
[Pharmacologic value of cyclic nucleotide phosphodiesterase inhibitors].
G Nemoz et al.
Annales pharmaceutiques francaises, 42(2), 99-112 (1984-01-01)
B Vellas et al.
Current Alzheimer research, 8(2), 203-212 (2011-01-13)
EHT0202 (etazolate hydrochloride) is a new compound exhibiting both potential disease-modifying and symptomatic treatment properties in Alzheimer's Disease increasing alpha-secretase activity and sAPP alpha secretion, as well as acting as a GABA-A receptor modulator and as a PDE-4 inhibitor. This
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