所有图片(1)
别名:
1-Ethyl-4-[(1-methylethylidene)hydrazino]1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester hydrochloride, SQ 20009
经验公式（希尔记法）:
C14H18N5O2 · HCl
检测方案
≥98% (TLC)
形式
solid
颜色
white
mp
193-194 °C
溶解性
H2O: >20 mg/mL (Solutions should be freshly prepared.)
储存温度
room temp
SMILES字符串
Cl.CCOC(=O)c1cnc2n(CC)ncc2c1N\N=C(\C)C
InChI
1S/C14H19N5O2.ClH/c1-5-19-13-10(8-16-19)12(18-17-9(3)4)11(7-15-13)14(20)21-6-2;/h7-8H,5-6H2,1-4H3,(H,15,18);1H
InChI key
GQJUGJHJUZSJLZ-UHFFFAOYSA-N
基因信息
human ... GABRB3(2562) , PRKAR1A(5573) , PRKAR1AP(5574) , PRKAR1B(5575) , PRKAR2A(5576) , PRKAR2B(5577)
生化/生理作用
Selective inhibitor of cAMP-specific phosphodiesterase.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
Jason Drott et al.
European journal of pharmacology, 634(1-3), 95-100 (2010-03-13)
Etazolate is a phosphodiesterase 4 (PDE4) inhibitor and GABAA receptor modulator that also stimulates alpha-secretase activity and neurotrophic soluble amyloid precursor protein (sAPPalpha) production, currently developed as a possible Alzheimer's disease therapeutic. In this study two doses of etazolate were
P L Wood et al.
The Journal of pharmacology and experimental therapeutics, 231(3), 572-576 (1984-12-01)
Using an extensively washed membrane preparation and standardized incubation conditions, the actions of benzodiazepine (BZ) receptor ligands were evaluated on [3H]flunitrazepam [+/- 10 microM gamma-aminobutyric acid (GABA)], [3H]muscimol (+/- 2.5 microM etazolate) and [35S]butyl bicyclophosphorothionate (TBPS) binding. Classical BZ receptor
B Vellas et al.
Current Alzheimer research, 8(2), 203-212 (2011-01-13)
EHT0202 (etazolate hydrochloride) is a new compound exhibiting both potential disease-modifying and symptomatic treatment properties in Alzheimer's Disease increasing alpha-secretase activity and sAPP alpha secretion, as well as acting as a GABA-A receptor modulator and as a PDE-4 inhibitor. This
P L Wood et al.
Progress in neuro-psychopharmacology & biological psychiatry, 8(4-6), 785-788 (1984-01-01)
The efficacy of coupling between the benzodiazepine receptor and chloride channel as well as the coupling to the GABA receptor is differentially affected by different benzodiazepine ligands. In general, the order of efficacy with regard to allosteric effects of benzodiazepine
[Pharmacologic value of cyclic nucleotide phosphodiesterase inhibitors].
G Nemoz et al.
Annales pharmaceutiques francaises, 42(2), 99-112 (1984-01-01)
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