product name
CNQX 二钠盐 水合物, ≥98% (HPLC), solid
质量水平
检测方案
≥98% (HPLC)
形式
solid
储存条件
protect from light
颜色
orange to red
溶解性
H2O: >2 mg/mL (warmed)
SMILES字符串
O.[Na+].[Na+].[O-]c1nc2cc(C#N)c(cc2nc1[O-])[N+]([O-])=O
InChI
1S/C9H4N4O4.2Na.H2O/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5;;;/h1-2H,(H,11,14)(H,12,15);;;1H2/q;2*+1;/p-2
InChI key
LCDWHGXMFAZHEO-UHFFFAOYSA-L
基因信息
human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140) , GRIA1(2890) , GRIA2(2891) , GRIA3(2892) , GRIA4(2893)
应用
CNQX二钠盐水合物用作：
- 神经元培养物中的竞争性非NMDA受体拮抗剂和竞争性 AMPA/红藻氨酸受体拮抗剂（110）
- 谷氨酸能阻滞剂，测量投射神经元的抑制性突触后电流（111）
- AMPA谷氨酸受体拮抗剂，用于前额叶皮层神经元（112）
生化/生理作用
CNQX（6-氰基-7-硝基喹喔啉-2,3-二酮）是强效、竞争性 AMPA/红藻氨酸受体拮抗剂。它是喹喔啉衍生物，也是非N-甲基-d-天冬氨酸（非-NMDA）谷氨酸受体拮抗剂。CNQX 通过 α-氨基-3-羟基-5-甲基异恶唑-4-丙酸受体（AMPAR）介导丘脑网状核去极化。 显示出对 AMPA/红藻氨酸受体具有微摩尔亲和力。
强效、竞争性 AMPA/红藻氨酸受体拮抗剂。
特点和优势
这种化合物是神经科学研究的特色产品。 点击此处 ，发现更多特色神经科学产品。在 sigma.com/discover-bsm 了解更多关于其他研究领域的生物活性小分子。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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