C144
1-（3-氯苯基）双胍 盐酸盐
solid
别名:
1-（间氯苯基）双胍 盐酸盐, N-（3-氯苯基）亚氨基二碳亚胺二酰胺 盐酸盐, m-CPBG 盐酸盐
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关于此项目
线性分子式:
ClC6H4NHC(NH)NHC(NH)NH2 · HCl
化学文摘社编号:
分子量:
248.11
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
InChI
1S/C8H10ClN5.ClH/c9-5-2-1-3-6(4-5)13-8(12)14-7(10)11;/h1-4H,(H6,10,11,12,13,14);1H
SMILES string
Cl[H].NC(=N)NC(=N)Nc1cccc(Cl)c1
InChI key
FOWAIJYHRWFTHR-UHFFFAOYSA-N
form
solid
color
white
mp
190-194 °C (lit.)
solubility
H2O: soluble
Gene Information
human ... HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242)
Biochem/physiol Actions
非常强效的5-HT35-羟色胺受体激动剂。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Citalopram, a selective serotonin reuptake inhibitor (SSRI), is frequently used in the treatment of major depressive disorders. In addition to its antidepressant features, citalopram shows some anticonvulsive properties at lower doses, whereas higher doses, ingested in cases of suicide, have
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Epilepsy research, 101(3), 217-227 (2012-05-15)
Citalopram is a selective serotonin reuptake inhibitor (SSRI), widely used in the treatment of depressive disorders. It has been shown that citalopram affects seizure susceptibility. Although the exact mechanism of these effects are not yet fully understood, recent data suggest
G J Kilpatrick et al.
European journal of pharmacology, 182(1), 193-197 (1990-06-21)
1-(m-Chlorophenyl)-biguanide (mCPBG) was examined and compared with three 5-HT3 receptor agonists in three 5-HT3 receptor models. mCPBG inhibited [3H]GR67330 binding to 5-HT3 receptors with high affinity (IC50 1.5 nM). mCPBG depolarized the rat vagus nerve with an EC50 one tenth
Wen Liu et al.
Alcohol (Fayetteville, N.Y.), 40(3), 167-176 (2007-04-10)
The objectives of the present study were to (a) examine the effects of activating serotonin-3 (5-HT3) receptors on dopamine (DA) release in the anterior and posterior ventral tegmental area (VTA) of Wistar rats and (b) determine if there are differences
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