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方案
≥98% (HPLC)
表单
powder
颜色
white
mp
172-176 °C (lit.)
溶解性
H2O: soluble (Solutions should be freshly prepared.)
ethanol: slightly soluble (Solutions should be freshly prepared.)
SMILES字符串
Br[H].COC(=O)C1=CCCN(C)C1
InChI
1S/C8H13NO2.BrH/c1-9-5-3-4-7(6-9)8(10)11-2;/h4H,3,5-6H2,1-2H3;1H
InChI key
AXOJRQLKMVSHHZ-UHFFFAOYSA-N
基因信息
human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)
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生化/生理作用
Muscarinic acetylcholine receptor agonist. A constituent of betel nut that may be carcinogenic on prolonged exposure. Cytotoxicity is reduced by antioxidants, such as reduced glutathione or N-acetyl-L-cysteine. Induces ADP ribosylation of histones and chromatid relaxation in spleen and bone marrow cells.
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
188.6 °F - Solvent
闪点(°C)
87 °C - Solvent
法规信息
新产品
J R Saikia et al.
Cancer letters, 139(1), 59-65 (1999-07-17)
Arecoline, the major alkaloid of betel nut (Areca catechu L.) and a suspected carcinogen, has been implicated in human cancers of various sites. A considerable portion of the world's population is constantly exposed to arecoline due to the habit of
A C Bartolomeo et al.
Neurobiology of learning and memory, 68(3), 333-342 (1997-12-17)
Male Sprague-Dawley rats, preoperatively trained in a 1-h delay non-match-to-position radial maze task, received bilateral stereotaxic injections of a selective cholinotoxin, ethylcholine aziridinium ion (AF64A: 3 nmol/3 microliters/lateral ventricle). Animals treated with AF64A made significantly more total postdelay errors than
A Chatterjee et al.
Cancer letters, 139(1), 23-31 (1999-07-17)
The carcinogenic potentiality of the major alkaloid of betel nut, arecoline (ARC), is well established. This study was undertaken to determine the differences in genotoxic effects of ARC when given by two different routes (oral administration (OA) and intraperitoneal injection
J H Jeng et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 37(7), 751-756 (1999-09-25)
Betel quid (BQ) chewing is associated with an increased risk of oral submucous fibrosis (OSF) and oral cancer in India and many south-east Asian countries. Recently, we have shown that arecoline is cytotoxic to cultured human oral mucosal fibroblasts. This
W H Moos et al.
Journal of pharmaceutical sciences, 81(10), 1015-1019 (1992-10-01)
Arecoline, arecaidine, and a series of derivatives, differing by the presence or absence of methyl groups at positions on the periphery of the molecule, were prepared, and their binding to muscarinic acetylcholine receptors was tested. On the basis of this
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