推荐产品
产品名称
5-阿扎胞苷, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
mp
226-232 °C (dec.) (lit.)
抗生素抗菌谱
viruses
作用机制
DNA synthesis | interferes
创始人
Celgene
储存温度
−20°C
SMILES字符串
NC1=NC(=O)N(C=N1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O
InChI
1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1
InChI key
NMUSYJAQQFHJEW-KVTDHHQDSA-N
基因信息
human ... DNMT1(1786) , DNMT3A(1788) , DNMT3B(1789)
正在寻找类似产品? 访问 产品对比指南
一般描述
应用
- 细胞诱导
- 研究其对牛胚胎间充质干细胞（bfMSC）的影响
- 研究其对人骨髓基质细胞（hBMSC）的影响
- 研究其对DNA甲基转移酶1（DNMT1）和Ras蛋白样激活剂 1（RASAL1）表达的影响
- 干扰DNA甲基化和组蛋白乙酰化
- 确定其对对照成纤维细胞转化的影响
- 用于光学相干断层扫描（OCT）和荧光素血管造影（FA)
- 重新激活Sal-like蛋白（SALL）3的表达
生化/生理作用
特点和优势
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Aquatic Chronic 1 - Carc. 1A - Muta. 2 - Repr. 1B - STOT RE 1
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
个人防护装备
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
What is the solution stability of Product No. A2385? That is, how should I store solutions of 5-Azacytidine?
We generally don't recommend storing solutions, since it has such poor solution stability. In Cancer Res., 61, 6331-6334 (2001), A. Chetcuti et al. describe preparing a 5 micromolar working concentration from a 5 Molar freshly prepared stock solution in DMSO.
What is Product No. A2385 (5-Azacytidine) used for?
This nucleoside analog has been used variously as an antitumor agent and as a mutagenic agent.
I need to perform an identity test on Product No. A2385 (5-Azacytidine). What would you recommend?
This means that each lot is tested according to the list of tests (left hand column), and must meet or exceed the specifications (right hand column). HPLC. The elemental analyses for carbon and nitrogen content are identity tests (albeit not absolutely conclusive identity tests). I would say that the HPLC, using a previous lot of A2385 as a control sample, provides the best evidence for identity and purity.
I just need to perform a purity assay on Product No. A2385 (5-Azacytidine). What would you recommend?
We assay the purity of this product by HPLC. If you would like to obtain a copy of our HPLC parameters/method, please contact your local Sigma-Aldrich Technical Service group.
My question is not addressed here, how can I contact Technical Service for assistance?
Ask a Scientist here.
商品
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门