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生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
PBS solution
分子量
antigen ~25 kDa
种属反应性
human
浓度
~0.5 mg/mL
技术
western blot: 1 μg/mL
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... PYCARD(29108)
一般描述
ASC/TMS1 is a CARD domain containing protein that is expressed in a variety of human and mouse tissues. Ectopic expression of ASC/TMS1 is known to inhibit cell survival and cause cell death in human breast cancer tissues by activating caspase-9. Furthermore, overexpression of ASC/TMS1 can induce DNA fragmentation,,,. Rabbit anti-ASC/TMS1 recognizes human ASC/TMS1 (approximately 25 kDa) by immunoblotting.
免疫原
synthetic peptide corresponding to amino acids 182-195 of human ASC.
应用
Rabbit anti-ASC/TMS1 antibody can be used for western blot assays at a concentration of 1 μg/ml.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Solution in phophate buffered saline containing 0.02% sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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法规信息
常规特殊物品
K E Conway et al.
Cancer research, 60(22), 6236-6242 (2000-12-05)
Gene silencing associated with aberrant methylation of promoter region CpG islands is an acquired epigenetic alteration that serves as an alternative to genetic defects in the inactivation of tumor suppressor and other genes in human cancers. The hypothesis that aberrant
J Masumoto et al.
The Journal of biological chemistry, 274(48), 33835-33838 (1999-11-24)
The cytoskeletal and/or nuclear matrix molecules responsible for morphological changes associated with apoptosis were identified using monoclonal antibodies (mAbs). We developed mAbs against Triton X-100-insoluble components of HL-60 cells pretreated with all-trans retinoic acid. In particular, one mAb recognized a
B B McConnell et al.
Cancer research, 60(22), 6243-6247 (2000-12-05)
Genetic and epigenetic alterations affecting proteins involved in apoptosis can contribute to the establishment and progression of cancer. Recently, our laboratory has isolated a novel gene, TMS1, that is aberrantly methylated and silenced in a significant proportion of human breast
J Masumoto et al.
Experimental cell research, 262(2), 128-133 (2001-01-05)
ASC (apoptosis-associated speck-like protein containing a CARD) was first identified as a cytosolic soluble protein that forms insoluble aggregates and enhances etoposide-induced apoptosis. We have cloned a murine ortholog of ASC (mASC) comprising 193 amino acids with a well-conserved pyrin
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