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质量水平
浓度
46.0-50.6% (methacrylic acid, calc. on solids content)
杂质
≤1 ppm arsenic (verified on random samples only)
≤1.00% coagulum content /particulate matter
≤10 ppm heavy metals (verified on random samples only)
灼烧残渣
≤0.1%
蒸发残留物 (140 °C, 30 min.)
28.5-31.5%
缺失
68.5-71.5% loss on drying, 140°C, 30 min.
pH值（酸碱度）
2.1-3.0
粘度
≤15 mPa.s(20 °C) (apparent viscosity)
3-15(20 °C) (mm2/s)
密度
1.062-1.072
SMILES字符串
O(CC)C(=O)C=C.OC(=O)C(=C)C
InChI
1S/C5H8O2.C4H6O2/c1-3-5(6)7-4-2;1-3(2)4(5)6/h3H,1,4H2,2H3;1H2,2H3,(H,5,6)
InChI key
GDCRSXZBSIRSFR-UHFFFAOYSA-N
应用
Kollicoat polymers can be employed as film coatings (intelligent surfaces) with controlled-release agents, for instant-release or sustained-release applications. Kollicoat polymers can be used with all standard coating equipment and are cost-effective, delivering maximum quality in terms of function, stability, and appearance. This research grade product is intended for use in R&D and development only.
分析说明
appearance of a film : clear
法律信息
Kollicoat is a registered trademark of BASF SE
C Guthmann et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 69(2), 667-674 (2008-01-30)
The drug substance SAG/ZK has a short biological half-life and because of its weakly basic nature a strong pH-dependent solubility was observed. The aim of this study was to develop a controlled release (cr) multiple unit pellet formulation for SAG/ZK
Comparative studies with Kollicoat MAE 30 D and Kollicoat MAE 30 DP in aqueous spray dispersions and enteric coatings on highly swellable caffeine cores.
Dangel C, Schepky G, Reich HB, Kolter K.
Drug Devel. Ind. Pharm., 26, 415-421 (2000)
A Dashevsky et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 58(1), 45-49 (2004-06-23)
The objective of this study was to obtain pH-independent release profiles from coated pellets containing drugs with pH-dependent solubility. pH-independent release of the basic model drug verapamil HCl was achieved by coating with a combination of the neutral polymer dispersions
H Kranz et al.
International journal of pharmaceutics, 380(1-2), 112-119 (2009-07-28)
The major aim of this study was to identify an efficient tool to adjust drug release patterns from aqueous and organic ethylcellulose (a gastrointestinal insoluble polymer) coated pellets and to evaluate the long term stability of the film coatings. Drug
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