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质量水平
方案
97.0-101.5%
表单
powder
技术
HPLC: suitable
gas chromatography (GC): suitable
mp
260-265 °C (dec.) (lit.)
应用
forensics and toxicology
pharmaceutical (small molecule)
作用机制
DNA synthesis | interferes
enzyme | inhibits
SMILES字符串
OC(=O)c1cc(ccc1O)\N=N\c2ccc(cc2)S(=O)(=O)Nc3ccccn3
InChI
1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+
InChI key
NCEXYHBECQHGNR-QZQOTICOSA-N
基因信息
human ... ALOX5(240) , PTGS1(5742) , PTGS2(5743)
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一般描述
化学结构：磺胺
柳氮磺胺吡啶(SSZ)属于磺胺类药物，可代谢为5-氨基水杨酸和磺胺吡啶。SSZ是抗菌剂（磺胺吡啶）和消炎剂（水杨酸）的反应产物。
应用
有关合适仪器技术的更多信息，请参考产品的分析证书。如需进一步支持，请联系技术服务。
柳氮磺胺吡啶在临床研究中用作分析标准品：
此外，还可作为分析参考标准，以通过酶联免疫吸附试验(ELISA)和荧光分光度技术量化生物样本和水样中的分析物。
- 研究其对多发性硬化症(MS)患者的治疗潜力。
- 通过抑制试验动物大鼠骨关节炎进展相关的软骨退变和疼痛研究其作为抗关节炎药物的作用。
此外，还可作为分析参考标准，以通过酶联免疫吸附试验(ELISA)和荧光分光度技术量化生物样本和水样中的分析物。
警示用语：
Danger
危险分类
Aquatic Chronic 2 - Carc. 2 - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 2
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Optimization of ionic liquid based dispersive liquid?liquid microextraction combined with dispersive micro-solid phase extraction for the spectrofluorimetric determination of sulfasalazine in aqueous samples by response surface methodology
Sadegh S and Oliaei S
Royal Society of Chemistry Advances, 6(114), 113551-113560 (2016)
Sushil Kumar et al.
The Cochrane database of systematic reviews, 10, CD008424-CD008424 (2012-10-19)
Ulcerative colitis (UC) is a chronic inflammatory condition of the colon characterized by episodes of disease activity and symptom-free remission.There is paucity of evidence regarding the efficacy and safety of complementary or alternative medicines for the management of UC. Curcumin
Johan A Karlsson et al.
Annals of the rheumatic diseases, 72(12), 1927-1933 (2012-12-01)
To compare EuroQol 5-Dimensions (EQ-5D) utility and quality-adjusted life-years (QALYs) in patients with early, methotrexate (MTX) refractory rheumatoid arthritis (RA), randomised to addition of infliximab (IFX) or sulfasalazine and hydroxychloroquine (SSZ+HCQ). RA-patients with symptoms <1 year were enrolled between 2002
M van den Broek et al.
Clinical and experimental rheumatology, 30(4 Suppl 73), S35-S38 (2012-10-20)
Targeted treatment is effective in the short term in achieving low disease activity or even remission in patients with rheumatoid arthritis (RA). The benefits of long-term targeted treatment are discussed based on the BeSt study results. The BeSt study has
Maarten Boers et al.
Annals of the rheumatic diseases, 72(3), 406-409 (2012-11-17)
Treatment of rheumatoid arthritis (RA) with tumour necrosis factor (TNF) antagonists changes the relationship between disease activity and progression of radiological joint damage ('disconnect'): patients who have little or no response of disease activity still show reductions in damage progression.
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