F8755
芬布芬
analytical standard
别名:
γ-氧-(1,1′-联苯)-4-丁酸
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关于此项目
线性分子式:
C6H5C6H4CO(CH2)2CO2H
化学文摘社编号:
分子量:
254.28
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
252-979-0
MDL number:
InChI key
ZPAKPRAICRBAOD-UHFFFAOYSA-N
InChI
1S/C16H14O3/c17-15(10-11-16(18)19)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9H,10-11H2,(H,18,19)
SMILES string
OC(=O)CCC(=O)c1ccc(cc1)-c2ccccc2
grade
analytical standard
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
184-187 °C (lit.)
application(s)
forensics and toxicology
pharmaceutical (small molecule)
veterinary
format
neat
Quality Level
Gene Information
human ... MMP2(4313), MMP3(4314), MMP9(4318)
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General description
Fenbufen belongs to the class of non-steroidal anti-inflammatory drugs, widely used as an antipyretic and analgesic in medical applications. Its mode of action involves the inhibition of cyclooxygenase enzyme and thereby prevents the synthesis of certain prostaglandins.
Application
Fenbufen may be used as an analytical reference standard for the quantification of the analyte in biological samples and pharmaceutical formulations using chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Y Hara et al.
The Journal of veterinary medical science, 59(10), 911-915 (1997-11-15)
Effects of central nervous stimulants on the spino-bulbo-spinal reflex potential were evaluated in anesthetized intact cats, and compared with those on segmental spinal reflex potentials in anesthetized spinal cats. In spinal cats, strychnine augmented polysynaptic reflex potential, picrotoxin inhibited dorsal
F Kamali et al.
Antimicrobial agents and chemotherapy, 42(5), 1256-1258 (1998-05-21)
The potential effects of concurrent administration of fenbufen and ciprofloxacin on central nervous system activity in healthy young subjects were investigated by electroencephalography (EEG). Visual analog scales (VAS) were used to assess subjective measures of concentration, vigilance, tension, and irritability.
Kun-I Lin et al.
Molecules (Basel, Switzerland), 15(12), 8796-8803 (2010-12-04)
The previous discoveries of butyl fenbufen amide analogs with antitumor effects were further examined. The amide analogs with 1, 3, 4 and 8 carbons chains were prepared in 70-80% yield. Fenbufen had no cytotoxic effects at concentrations ranging from 10
Huarong Zhang et al.
European journal of mass spectrometry (Chichester, England), 12(5), 291-299 (2007-04-04)
The inclusion complexes of four ligands binding to cyclodextrins (CDs) were studied by electrospray ionization mass spectrometry (ESI-MS) and the dissociation constants of the complexes were obtained. The 1:1 stoichiometric inclusion complex was found in the system of CD and
Arkadiusz Pomykalski et al.
Acta poloniae pharmaceutica, 62(3), 171-176 (2005-10-01)
A methods for the determination of fenbufen and ketoprofen in pharmaceuticals by classical spectrophotometry--zero order derivative, first and second order derivatives spectrophotometry is described. using "peak-peak" (P-P) and, "peak-zero" (P-O) measurements. The calibration curves are linear within the concentration range
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