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Merck
CN

22880

Sigma-Aldrich

氯乙酰氯

purum, ≥99.0% (GC)

别名:

Chloroacetic chloride

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About This Item

线性分子式:
ClCH2COCl
CAS号:
分子量:
112.94
Beilstein:
605439
EC 号:
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22

蒸汽密度

3.9 (vs air)

质量水平

蒸汽压

60 mmHg ( 41.5 °C)

等级

purum

检测方案

≥99.0% (GC)

形式

liquid

折射率

n20/D 1.453 (lit.)
n20/D 1.453

bp

105-106 °C (lit.)

mp

−22 °C (lit.)

溶解性

water: insoluble

密度

1.419 g/mL at 20 °C
1.418 g/mL at 25 °C (lit.)

SMILES字符串

ClCC(Cl)=O

InChI

1S/C2H2Cl2O/c3-1-2(4)5/h1H2

InChI key

VGCXGMAHQTYDJK-UHFFFAOYSA-N

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一般描述

氯乙酰氯是一种脂肪族酰氯。

应用

氯乙酰氯可用于制备:
  • 通过吡啶-2-胺的N-酰化作用制备2-氯-N-(吡啶-2-基)乙酰胺
  • 通过 N,N-二甲基甲酰胺与纤维素反应,制备氯乙酰纤维素
  • 在回流甲苯中存在碱的条件下,通过与1,3-苯并噻嗪反应制备苯并噻嗪类衍生物
  • 通过与3,5-二芳基-4,5-二氢吡唑反应制备2-氯-1-(3,5-二芳基-4,5-二氢吡唑-1-基)-乙酮
  • 在微波条件下,通过与氯代靛红反应,制备氯乙酰基
在嘧啶酮与壳聚糖接枝过程中,它充当交联剂。
氯乙酰氯用于合成 N-肼基乙酰磺酰胺

警示用语:

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Dam. 1 - Skin Corr. 1A - STOT RE 1

靶器官

Lungs

补充剂危害

WGK

WGK 3

闪点(°F)

closed cup

闪点(°C)

closed cup

个人防护装备

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

法规信息

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分析证书(COA)

Lot/Batch Number

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Application of microwave induced Delepine reaction to the facile one pot synthesis of 7-substituted 1, 3-dihydro-2h-[1, 4]-benzodiazepin-2-one-5-methyl carboxylates from the corresponding 1-chloroacetyl isatins.
Sharma P, et al.
International Journal of Chemical Sciences, 8(1) (2010)
Oana Maria Parasca et al.
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi, 117(1), 238-243 (2014-02-11)
Infections caused by bacterial species are common in immunocompromised patients and carry significant treatment costs and mortality. The emerging resistance of microorganisms to some synthetic antimicrobial agents makes it necessary to continue the research for new antimicrobial drugs. To design
Synthesis and Anticancer Activity of Isatin-Based Pyrazolines and Thiazolidines Conjugates.
Havrylyuk D, et al.
Arch. Pharm. (Weinheim), 344(8), 514-522 (2011)
Ameya A Chavan et al.
Molecules (Basel, Switzerland), 12(11), 2467-2477 (2007-12-11)
2-Aminobenzothiazole-6-carboxylic acid (1), on condensation with chloroacetyl chloride yielded 2-(2-chloroacetylamino)benzothiazole-6-carboxylic acid (2), which on amination with hydrazine hydrate yielded in turn 2-(2-hydrazinoacetylamino)benzo-thiazole-6-carboxylic acid (3). Compound 3, on condensation with various aromatic aldehydes afforded a series of 2-{2-[N'-(arylidene)hydrazino]acetylamino}benzothiazole-6-carboxylic acids 4a-h, which
T F Dowsley et al.
Chemico-biological interactions, 95(3), 227-244 (1995-04-14)
1,1-Dichloroethylene (DCE) requires cytochrome P450-catalyzed bioactivation to electrophilic metabolites (1,1-dichloroethylene oxide, 2-chloroacetyl chloride and 2,2-dichloroacetaldehyde) to exert its cytotoxic effects. In this investigation, we examined the reactions of these metabolites with glutathione by spectroscopic and chromatographic techniques. In view of

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