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蒸汽密度
3.9 (vs air)
质量水平
蒸汽压
60 mmHg ( 41.5 °C)
检测方案
98%
折射率
n20/D 1.453 (lit.)
bp
105-106 °C (lit.)
mp
−22 °C (lit.)
密度
1.418 g/mL at 25 °C (lit.)
SMILES字符串
ClCC(Cl)=O
InChI
1S/C2H2Cl2O/c3-1-2(4)5/h1H2
InChI key
VGCXGMAHQTYDJK-UHFFFAOYSA-N
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一般描述
氯乙酰氯被用作氯化试剂、酰化试剂、单氯酮烯的前体，以及环化的合成砌块。
氯乙酰氯在合成二级胺取代的氰基吡唑啉衍生物过程中引起氰基吡唑啉的酰化。
氯乙酰氯在合成二级胺取代的氰基吡唑啉衍生物过程中引起氰基吡唑啉的酰化。
应用
氯乙酰氯可用于聚(甲基丙烯酸缩水甘油酯)的氯乙酰化和化学改性。氯乙酰氯用于研究大鼠和人肝微粒体对氯乙酰胺除草剂的体外代谢。氯乙酰氯用于合成一些具有抗利什曼原虫活性的新型喹啉衍生物。
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Dam. 1 - Skin Corr. 1A - STOT RE 1
靶器官
Lungs
补充剂危害
WGK
WGK 3
闪点(°F)
closed cup
闪点(°C)
closed cup
个人防护装备
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
危险化学品
S Coleman et al.
Environmental health perspectives, 108(12), 1151-1157 (2001-01-03)
Acetochlor [2-chloro-N-(ethoxymethyl)-N-(2-ethyl-6-methyl-phenyl)-acetamide], alachlor [N-(methoxymethyl)-2-chloro-N-(2, 6-diethyl-phenyl)acetamide], butachlor [N-(butoxymethyl)-2-chloro-N-(2,6-diethyl-phenyl)acetamide], and metolachlor [2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl) acetamide] are pre-emergent herbicides used in the production of agricultural crops. These herbicides are carcinogenic in rats: acetochlor and alachlor cause tumors in the nasal turbinates, butachlor causes stomach tumors
Kenawy el-R et al.
Journal of controlled release : official journal of the Controlled Release Society, 50(1-3), 145-152 (1998-08-01)
Polymers with antibacterial activity have been synthesized by chemical modification of poly(glycidyl methacrylate). The glycidyl methacrylate was polymerized by the free radical polymerization technique. The poly(glycidyl methacrylate) was hydrolyzed and was chloroacetylated using chloroacetyl chloride. The chloroacetylated product was modified
Niranjan P Sahu et al.
Bioorganic & medicinal chemistry, 10(6), 1687-1693 (2002-04-09)
Some novel quinoline derivatives were prepared and tested for antileishmanial activity. 2-(2-Methylquinolin-4-ylamino)-N-phenylacetamide (2) was found to be significantly more active than the standard antileishmanial drug sodium antimony gluconate (SAG) in reducing the parasite load both in the spleen and liver
Chloroacetyl Chloride
George AO, et al.
eEROS (Encyclopedia of Reagents for Organic Synthesis) (2001)
Jin Hee Ahn et al.
Bioorganic & medicinal chemistry letters, 14(17), 4461-4465 (2004-09-11)
A new series of cyano-pyrazoline derivatives with secondary amine at P-2 site was synthesized through achiral and chiral synthetic methods and evaluated for their ability to inhibit dipeptidyl peptidase IV (DP-IV). Compound 5i revealed good in vivo efficacy (ED50: 4.1
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