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安全信息

TGFBMAG-64K-03

Millipore

MILLIPLEX® TGFß Magnetic Bead 3 Plex Kit - Immunology Multiplex Assay

for quantification of TGFß1, TGFß2 and TGFß3 in multiple species

别名:

3 Plex TGFß Assay, TGFß Magnetic Bead Kit

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About This Item

UNSPSC代码:
12161503
eCl@ss:
32161000
NACRES:
NA.47

质量水平

200

种属反应性

horse, human, nonhuman primates, feline, pig, mouse, rat, canine

制造商/商品名称

Milliplex®

assay range

accuracy: 62-128%
sensitivity: 8-12 pg/mL
standard curve range: 9.8-2,500 pg/mL

技术

multiplexing: suitable

相容性

configured for Premixed

检测方法

fluorometric (Luminex xMAP)

运输

wet ice

相关类别

一般描述

The transforming growth factor beta (TGFβ) system, a superfamily of cytokines as well as signaling pathways, is highly conserved throughout the animal kingdom. TGFβ functions in immune cell development, angiogenesis, wound healing and embryonic development, bone development and plays a critical role in immune response, heart disease, and cancer. In its normal state TGFβ is one of the few classes of proteins able to inhibit cell growth by halting mitosis at the G1 state, inducing cell differentiation or apoptosis. However, during oncogenesis mutations in the TGFβ signaling pathway result in tumor cell resistance to the effects of normally functioning TGFβ, causing proliferation without regulation. Initial research suggests that VE-cadherin may enhance the mutated TGFβ signaling pathway.

The MILLIPLEX® TGFβ 1, 2 and 3 Panel is a 3-plex kit to be used for the simultaneous quantification of the following analytes in serum, plasma and cell/tissue culture samples: TGFβ1, TGFβ2, TGFβ3. The Luminex® xMAP® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.

Panel Type: Cytokines/Chemokines

应用

  • Analytes: TGF-β1, TGF-β2, TGF-β3
  • Recommended Species: In addition to human, TGF-β1, TGF-β2, TGF-β3 can be detected in the serum of the following species: mouse, rat, mini pig, hamster, guinea pig, rhesus monkey and cynomolgus monkey samples. Additionally, TGF-β1 and TGF-β2 can be detected in the serum of horse, rabbit and canine. However, the exact amount of cross reactivity has not been determined.
  • NOTE: This assay requires a sample acidification treatment using the provided reagents and protocol.
  • Recommended Sample Types: Serum, plasma, cell/tissue culture supernatants and lysates
  • Recommended Sample Dilution: 25 μL per well of a 1:30 dilution after acidification treatment of serum and plasma samples; cell/tissue culture samples may require dilution prior to acidification treatment (see protocol for details).
  • Assay Run Time: Overnight (16-18 hours) at 2-8°C or alternatively, 2 hours at room temperature (20-25°C).
  • Research Category: Inflammation & Immunology
  • Research Subcategory: Cardiovascular Disease, Chronic Inflammatory Disease, Immune Disorders, Inflammatory Disease, Rheumatoid Arthritis

法律信息

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

警示用语：

Danger

危险分类

Aquatic Chronic 2 - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1A - Skin Sens. 1

储存分类代码

8A - Combustible corrosive hazardous materials

WGK

WGK 3

法规信息

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Samantha M Logan et al.
PeerJ, 7, e8116-e8116 (2019-11-26)
To conserve energy in times of limited resource availability, particularly during cold winters, hibernators suppress even the most basic of physiologic processes. Breathing rates decrease from 40 breaths/minute to less than 1 breath/min as they decrease body temperature from 37
Julien Fourcade et al.
JCI insight, 3(14) (2018-07-27)
CD4+ Tregs impede T cell responses to tumors. They express multiple inhibitory receptors that support their suppressive functions, including T cell Ig and ITIM domain (TIGIT). In melanoma patients, we show that Tregs exhibit increased TIGIT expression and decreased expression
Beate Obermüller et al.
Nutrients, 12(7) (2020-07-12)
Malignant diseases can cause tumor-associated cachexia (TAC). Supplementation with prebiotic non-digestible carbohydrates exerts positive metabolic effects in experimental oncologic diseases. The aim of this project was to assess the effect of prebiotic supplementation with OMNi-LOGiC® FIBRE on intestinal microbiome, bacterial
Lerin R Luckett-Chastain et al.
Experimental dermatology, 26(8), 697-704 (2016-11-29)
It been shown that IL-6 modulates TGF-β1 expression in fibroblasts, however, what role IL-6 plays concerning TGF-βR expression and function in skin is unknown. Therefore, the aim of this study was to investigate the mechanism by which IL-6 might modulates
Lingwen Ying et al.
Diabetes, metabolic syndrome and obesity : targets and therapy, 14, 4661-4670 (2021-12-09)
We aimed to explore the immunological characteristics and cytokine profile of the initial stage of type 1 diabetes. In total, 123 age- and sex-matched subjects with newly diagnosed classic type 1 diabetes mellitus (T1ADM), fulminant type 1 diabetes mellitus (FT1DM)
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