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安全信息

SCC007

Sigma-Aldrich

ReNcell CX人神经祖细胞系

ReNcell CX is an immortalized human neural progenitor cell line with the ability to readily differentiate into neurons & glial cells.

别名:

Human NSC Line, Human Neural Stem Cell Line, Human Neural Stem Cells

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About This Item

UNSPSC代码:
41106509
eCl@ss:
32011203
NACRES:
NA.75

生物来源

human

质量水平

100

制造商/商品名称

Chemicon®
ReNcell

技术

cell culture | stem cell: suitable

输入

sample type neural stem cell(s)

运输

liquid nitrogen

相关类别

一般描述

ReNcell CX是一种永生化的人神经祖细胞系，具有易于分化为神经元和神经胶质细胞的能力。 ReNcell CX源自人胎脑的皮质区域。 通过用c-myc癌基因进行逆转录病毒转导而永生化，该细胞系在层粘连蛋白上以单层快速生长，倍增时间为20-30小时。 核型分析表明，即使经过长时间传代（>45代），ReNcell CX仍可在培养物中保留正常的二倍体核型。 ReNcell CX由ReNeuron Group plc开发，ReNeuron Group plc是一家专门将人体体干细胞用于治疗的生物技术公司。 ReNcell CX可用于多种研究应用，例如神经毒性、神经发生、电生理学、神经递质和受体功能的研究。 ReNcell CX细胞是按照法律和伦理的方式获得的，符合现行的当地知情同意程序。

ReNcell现在用于阿尔茨海默′病的3D细胞模型！
Tanzi, R and Kim, DY et. al. A three-dimensional human neural cell culture model of Alzheimer′s disease.Nature.2014 Nov 13;515(7526):274-8.
（发表在Nature上）
产品来源：人类皮质脑组织

细胞系描述

神经干细胞

应用

研究类别
干细胞研究

组分

> 1x106 活ReNcell CX细胞

质量

已经验证了每批ReNcell CX细胞的巢蛋白和Sox 2的高水平表达及其自我更新和多谱系分化能力（请参见数据表图）。 通过染色体扩散评估，细胞还显示出正常的核型，并且支原体测试为阴性。已对孕妇血液进行了HIV、HTLV、乙型和丙型肝炎筛查。

储存及稳定性

当在推荐的储存条件（液氮）下储存时，ReNcell CX细胞在有效期内保持稳定。 请勿暴露于高温下。 到期后，请丢弃所有剩余的试剂。 我们建议在十代内使用细胞。

其他说明

根据产品文件中详述的“学术使用协议”的条款，本产品预期仅用于销售和销售给学术机构，以供内部学术研究使用。有关任何其他用途的信息，请联系licensing@emdmillipore.com。

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

仅供研究使用。在法国，在用于科研目的时（包括进口和出口活动（《公共健康法》第L 1211-1条，第2节））该产品为管制品。购买者（即最终用户）需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。

WGK

WGK 3

闪点(°F)

does not flash

闪点(°C)

does not flash

法规信息

高风险级别生物产品-Merck

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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Suojun Zhang et al.
International journal of oncology, 45(5), 1989-1996 (2014-09-02)
Glioma stem cells (GSCs), characterized by self-renewal, multi-potentiality and tumorigenicity, are responsible for the tumor propagation, recurrence and resistance to traditional treatments, representing a critical therapeutic target. Neural stem cells (NSCs) possess inherent tropism to brain tumor cells and inhibit
Mia C Borlongan et al.
Neuromolecular medicine, 23(4), 540-548 (2021-04-09)
The present in vitro study showed that IL-2/IL-2R antibody complex facilitates Treg-induced neuroprotection in the oxygen glucose deprivation/reoxygenation (OGD/R) model of stroke. First, we examined the role of IL-2/IL-2R-treated Tregs in OGD/R-exposed rat primary cortical cells (PCCs), which represent the
Greg Maguire et al.
Physiological reports, 7(9), e14072-e14072 (2019-05-03)
Evidence suggests that adult stem cell types and progenitor cells act collectively in a given tissue to maintain and heal organs, such as muscle, through a release of a multitude of molecules packaged into exosomes from the different cell types.
Stephanie M Bilinovich et al.
International journal of environmental research and public health, 17(20) (2020-10-15)
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by disruptions in social communication and behavioral flexibility. Both genetic and environmental factors contribute to ASD risk. Epidemiologic studies indicate that roadway vehicle exhaust and in utero exposure to diesel particulate
Liang Luo et al.
Scientific reports, 7, 40463-40463 (2017-01-12)
There has been recently been increased interest in the plasticity of human umbilical cord mesenchymal stem cells (UMSCs) and their potential in the treatment of neurological disorders. In this study, UMSCs were transdifferentiated into neural stem-like cells (uNSCL), these cells
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Derivation of Functional Oligodendrocyte Progenitor Cells (OPCs) from Human Neural Stem Cell Lines

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实验方案

Alzheimer’s In A Dish™: 3D Neural Stem Cell Models of Alzheimer's Disease

A stem cell culture protocol to generate 3D NSC models of Alzheimer’s disease using ReNcell human neural stem cell lines.

Neural Stem Cell Culture Protocols

Step-by-step culture protocols for neural stem cell culture including NSC isolation, expansion, differentiation and characterization.

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