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Merck
CN

5.00667

SAFC

一磷酸硫胺氯化物 二水合物

EMPROVE® API

制药生产

别名:

氯化亚氨基磷酸酯

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About This Item

经验公式(希尔记法):
C12H18ClN4O4PS · 2H2O
分子量:
416.82
Beilstein:
3844977
MDL编号:
UNSPSC代码:
12352107
EC索引号:
208-536-9

蒸汽压

<1 Pa ( 50 °C)

质量水平

产品线

EMPROVE® API

形式

solid

pH值(酸碱度)

2-3 (20 °C, 100 g/L in H2O)

mp

135 °C (decomposition)

溶解性

176 g/L

密度

1.53 g/cm3 at 20 °C

堆积密度

670 kg/m3

应用

liquid formulation
pharmaceutical
semi-solid formulation
solid formulation

储存温度

2-25°C

SMILES字符串

[Cl-].Cc1ncc(C[n+]2csc(CCOP(O)(O)=O)c2C)c(N)n1

InChI

1S/C12H17N4O4PS.ClH/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19);1H

InChI key

GUGWNSHJDUEHNJ-UHFFFAOYSA-N

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一般描述

We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. As part of our EMPROVE® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

应用

Thiamine phosphoric acid ester chloride dihydrate is a source for Vitamin B1 for use in clinical nutrition, vitamin supplements and infusion for Vitamin B1 deficiency. Thiamine phosphoric acid ester chloride dihydrate Emprove® API is manufactured according to ICH Q7 guidelines. An ASMF is available.
This product is part of our proprietary Viscosity Reduction Platform and suitable for highly concentrated protein-based formulations.

法律信息

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Skin Sens. 1

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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商品

This overview describes how use of viscosity-reducing excipients can address viscosity challenges in high concentration tangential flow filtration (TFF) and improve process economics.

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