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Merck
CN

1.03893

SAFC

苯磺酸

EMPROVE® EXPERT

制药生产

别名:

Benzene sulphonic acid, Benzenesulphonic acid, Besylic acid, Phenylsulfonic acid, Phenylsulphonic acid

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About This Item

线性分子式:
C6H5SO3H
CAS号:
分子量:
158.18
Beilstein:
742513
EC 号:
MDL编号:
UNSPSC代码:
12352005

生物来源

synthetic

质量水平

产品线

EMPROVE® EXPERT

表单

crystalline

技术

API processing | cocrystal formation: suitable
API processing | salt formation: suitable

杂质

endotoxins, low

应用

liquid formulation
parenterals
pharmaceutical

SMILES字符串

OS(=O)(=O)c1ccccc1

InChI

1S/C6H6O3S/c7-10(8,9)6-4-2-1-3-5-6/h1-5H,(H,7,8,9)

InChI key

SRSXLGNVWSONIS-UHFFFAOYSA-N

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一般描述

For protein-based therapeutics, such as monoclonal antibodies (mAbs) or plasma derived proteins, often highly concentrated protein formulations are required to meet intended dosing regimens. However, this usually comes with elevated viscosities and presents a challenge in the manufacturing process and final formulation. Our Viscosity Reduction Excipient Platform reduces the viscosity and helps overcome challenges associated with highly concentrated protein solutions.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation.
Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

应用

The Viscosity Reduction Platform is based on the combination of two new excipients, one amino acid component with one anionic component, that together can better reduce protein viscosity beyond levels achieved with single excipients. Also, combining the two components enables a balance of viscosity reduction and protein stabilization. Benzenesulfonic Acid Emprove® Expert is part of this new proprietary technology platform.

包装

1038930500 / 500g / Glass bottle
1038931000 / 1kg / Glass bottle

法律信息

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

CorrosionExclamation mark

警示用语:

Danger

危险声明

危险分类

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B

储存分类代码

8A - Combustible corrosive hazardous materials

WGK

WGK 1


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商品

This overview describes how use of viscosity-reducing excipients can address viscosity challenges in high concentration tangential flow filtration (TFF) and improve process economics.

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