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线性分子式:
C6H5SO3H
化学文摘社编号:
分子量:
158.18
EC Number:
202-638-7
UNSPSC Code:
12352005
MDL number:
Beilstein/REAXYS Number:
742513
产品名称
苯磺酸, EMPROVE® EXPERT
InChI key
SRSXLGNVWSONIS-UHFFFAOYSA-N
InChI
1S/C6H6O3S/c7-10(8,9)6-4-2-1-3-5-6/h1-5H,(H,7,8,9)
SMILES string
OS(=O)(=O)c1ccccc1
biological source
synthetic
product line
EMPROVE® EXPERT
form
crystalline
technique(s)
API processing | cocrystal formation: suitable
API processing | salt formation: suitable
impurities
endotoxins, low
application(s)
liquid formulation
parenterals
pharmaceutical
Quality Level
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Application
The Viscosity Reduction Platform is based on the combination of two new excipients, one amino acid component with one anionic component, that together can better reduce protein viscosity beyond levels achieved with single excipients. Also, combining the two components enables a balance of viscosity reduction and protein stabilization. Benzenesulfonic Acid Emprove® Expert is part of this new proprietary technology platform.
General description
For protein-based therapeutics, such as monoclonal antibodies (mAbs) or plasma derived proteins, often highly concentrated protein formulations are required to meet intended dosing regimens. However, this usually comes with elevated viscosities and presents a challenge in the manufacturing process and final formulation. Our Viscosity Reduction Excipient Platform reduces the viscosity and helps overcome challenges associated with highly concentrated protein solutions.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation.
Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation.
Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.
Packaging
1038930500 / 500g / Glass bottle
1038931000 / 1kg / Glass bottle
1038931000 / 1kg / Glass bottle
Legal Information
Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 1
商品
This overview describes how use of viscosity-reducing excipients can address viscosity challenges in high concentration tangential flow filtration (TFF) and improve process economics.
相关内容
User Guide on Experimental Procedures to evaluate the viscosity reduction platform.
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