400052
潮霉素B，来源于链霉菌属，无菌过滤溶液，溶剂为PBS，经细胞培养测试
Hygromycin B is an aminoglycoside antibiotic that inhibits the growth of prokaryotic and eukaryotic microorganisms and mammalian cells. Inhibits protein synthesis by interfering with the translocation of the 70S ribosome and causes misreading of mRNA.
别名:
潮霉素B，来源于链霉菌属，无菌过滤溶液，溶剂为PBS，经细胞培养测试
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About This Item
推荐产品
质量水平
方案
≥85% (HPLC and TLC)
表单
liquid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
运输
ambient
储存温度
2-8°C
InChI
1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6+,7+,8-,9+,10-,11+,12-,13-,14-,15-,16+,17+,18-,19+,20?/m1/s1
InChI key
GRRNUXAQVGOGFE-KPBUCVLVSA-N
一般描述
无菌液体制剂，货号400050。
潮霉素B是一种氨基糖苷类抗生素，可抑制原核和真核微生物以及哺乳动物细胞的生长。通过干扰70S核糖体的转运来抑制蛋白质合成，并引起mRNA的误读。对潮霉素B的抗性是通过一段基因所编码的潮霉素B磷酸转移酶对药物进行磷酸化并使其失活来实现的。潮霉素B已被用于选择在包括细菌、原生动物、酵母、真菌、植物和哺乳动物细胞在内的多种细胞中携带潮霉素B抗性基因的突变体。用于哺乳动物细胞选择的典型浓度在0.05至1 mg/ml之间。对于每种细胞类型，必须通过经验确定适当的使用浓度。
应用
潮霉素B是一种氨基糖苷类抗生素，可抑制原核和真核微生物以及哺乳动物细胞的生长。通过干扰70S核糖体的转运来抑制蛋白质合成，并引起mRNA的误读。
生化/生理作用
功效：≥1000 U/mg
警告
毒性：高毒性 & 致癌性/致畸性（I）
外形
溶于无菌过滤PBS（pH 7.2）中的50 mg/ml活性抗生素。
其他说明
Sugimoto, K., et al. 1994.Plant J.5, 863.
Lee, M.G., and van der Ploeg, L.H.1991.Gene105, 255.
Salauze, D., et al. 1990.Antimicrob.Agents Chemother.34, 1915.
Cullen, D., et al. 1987.Gene57, 21.
Rao, S.N., et al. 1983.Antimicrob.Agents Chemother.24, 689.
Santerre, R.F., et al. 1984.Gene30, 147.
Gonzalez, A., et al. 1978.Biochim.Biophys.Acta521, 459.
Lee, M.G., and van der Ploeg, L.H.1991.Gene105, 255.
Salauze, D., et al. 1990.Antimicrob.Agents Chemother.34, 1915.
Cullen, D., et al. 1987.Gene57, 21.
Rao, S.N., et al. 1983.Antimicrob.Agents Chemother.24, 689.
Santerre, R.F., et al. 1984.Gene30, 147.
Gonzalez, A., et al. 1978.Biochim.Biophys.Acta521, 459.
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法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险声明
危险分类
Acute Tox. 1 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal
储存分类代码
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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Antibiotic kill curve is a dose response experiment in which mammalian cells are subjected to increasing amounts of selection antibiotic
抗生素杀灭曲线是一项剂量响应实验，通过逐渐增大施加在哺乳动物细胞中的备选抗生素剂量进行测定。
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