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Merck
CN

400052

潮霉素B，来源于链霉菌属，无菌过滤溶液，溶剂为PBS，经细胞培养测试

Hygromycin B is an aminoglycoside antibiotic that inhibits the growth of prokaryotic and eukaryotic microorganisms and mammalian cells. Inhibits protein synthesis by interfering with the translocation of the 70S ribosome and causes misreading of mRNA.

别名:

潮霉素B，来源于链霉菌属，无菌过滤溶液，溶剂为PBS，经细胞培养测试

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关于此项目

经验公式（希尔记法）:
C20H37N3O13
化学文摘社编号:
31282-04-9
分子量:
527.52
UNSPSC Code:
12352200
MDL number:
MFCD06795479

主要文件

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产品名称

潮霉素B，来源于链霉菌属，无菌过滤溶液，溶剂为PBS，经细胞培养测试, Hygromycin B is an aminoglycoside antibiotic that inhibits the growth of prokaryotic and eukaryotic microorganisms and mammalian cells. Inhibits protein synthesis by interfering with the translocation of the 70S ribosome and causes misreading of mRNA.

InChI

1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6+,7+,8-,9+,10-,11+,12-,13-,14-,15-,16+,17+,18-,19+,20?/m1/s1

InChI key

GRRNUXAQVGOGFE-KPBUCVLVSA-N

assay

≥85% (HPLC and TLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Application

潮霉素B是一种氨基糖苷类抗生素，可抑制原核和真核微生物以及哺乳动物细胞的生长。通过干扰70S核糖体的转运来抑制蛋白质合成，并引起mRNA的误读。

Biochem/physiol Actions

功效：≥1000 U/mg

Disclaimer

毒性：高毒性 & 致癌性/致畸性（I）

General description

无菌液体制剂，货号400050。
潮霉素B是一种氨基糖苷类抗生素，可抑制原核和真核微生物以及哺乳动物细胞的生长。通过干扰70S核糖体的转运来抑制蛋白质合成，并引起mRNA的误读。对潮霉素B的抗性是通过一段基因所编码的潮霉素B磷酸转移酶对药物进行磷酸化并使其失活来实现的。潮霉素B已被用于选择在包括细菌、原生动物、酵母、真菌、植物和哺乳动物细胞在内的多种细胞中携带潮霉素B抗性基因的突变体。用于哺乳动物细胞选择的典型浓度在0.05至1 mg/ml之间。对于每种细胞类型，必须通过经验确定适当的使用浓度。

Other Notes

Sugimoto, K., et al. 1994.Plant J.5, 863.
Lee, M.G., and van der Ploeg, L.H.1991.Gene105, 255.
Salauze, D., et al. 1990.Antimicrob.Agents Chemother.34, 1915.
Cullen, D., et al. 1987.Gene57, 21.
Rao, S.N., et al. 1983.Antimicrob.Agents Chemother.24, 689.
Santerre, R.F., et al. 1984.Gene30, 147.
Gonzalez, A., et al. 1978.Biochim.Biophys.Acta521, 459.
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Physical form

溶于无菌过滤PBS（pH 7.2）中的50 mg/ml活性抗生素。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal

存储类别

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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