Coagulation Factor α-XIIa, Human Plasma

Native coagulation factor α-XIIa from human plasma prepared from homogeneous Factor XII using dextran sulfate. Dextran sulfate is removed after activation. α-XIIa is a serine protease responsible for activation of Factor XI to Factor XIa. Factor XIIa and prekallikrein are thought to be involved in a reciprocal activation mechanism whereby Factor XIIa activates prekallikrein to kallikrein, which in turn converts Factor XII to Factor XIIa.

Please refer to vial label for lot-specific concentration.

Toxicity: Standard Handling (A)

In 150 mM NaCl, 4 mM sodium acetate buffer, pH 5.3.

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Following initial thaw, aliquot and freeze (-70°C).

Clotting activity is determined by comparison to a standard curve produced using normal pooled human plasma

homogeneous by SDS-PAGE

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany