检测方案
>99% (TLC)
形式
powder
包装
pkg of 1 × 1 mg (810219P-1mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 810219P
运输
dry ice
储存温度
−20°C
一般描述
C12-NBD Sphingomyelin is a fluorescent analog of biologically active molecule, sphingomyelin. Sphingomyelin is predominantly found in the animal plasma membrane. It is abundantly present as component of cell membranes in mammals, nematodes, protozoa.
应用
C12-NBD-sphingomyelin has been used as a substrate to test substrate specificity of neutral ceramidase orthologue encoded by AsahA gene.
生化/生理作用
Sphingomyelin (SM) is produced from phosphatidylcholine and ceramide on the cell surface and in lumen of the Golgi. SM′s high packing density and affinity to sterols form a rigid barrier to the extracellular environment. SM is also involved in the formation of lipid rafts in cell membranes, which perform important functions in signal transduction and membrane trafficking.
包装
5 mL Amber Glass Screw Cap Vial (810219P-1mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
Sawaki Tada et al.
FEMS microbiology letters, 298(2), 157-165 (2009-08-05)
Ceramide is an important molecule not only structurally but also regulationally as a modulator of various cellular events. Ceramidase (CDase) are classified into three different types (acid, alkaline, and neutral CDases). Neutral CDase could play an important role in the
Hyun-Seok Lee et al.
International journal of molecular sciences, 21(3) (2020-02-08)
Human epidermis is positioned at the interface with the external environment, protecting our bodies against external challenges, including air pollutants. Emerging evidence suggests that diesel particulate extract (DPE), a major component of air pollution, leads to impairment of diverse cellular
Characterization of a neutral ceramidase orthologue from Aspergillus oryzae
Tada S, et al.
FEMS Microbiology Letters, 298(2), 157-165 (2009)
Fluorescent and Luminescent Probes for Biological Activity (1999)
Klazien Huitema et al.
The EMBO journal, 23(1), 33-44 (2003-12-20)
Sphingomyelin (SM) is a major component of animal plasma membranes. Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, yielding diacylglycerol as a side product. This reaction is catalysed by SM synthase, an enzyme whose biological potential can
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