检测方案
>99% (TLC)
形式
liquid
包装
pkg of 1 × 1 mL (810209X-1mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 810209X
浓度
1 mg/mL (810209X-1mg)
运输
dry ice
储存温度
−20°C
InChI
1S/C30H49N5O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-27(37)25(23-36)32-28(38)19-16-14-17-22-31-24-20-21-26(35(39)40)30-29(24)33-41-34-30/h15,18,20-21,25,27,31,36-37H,2-14,16-17,19,22-23H2,1H3,(H,32,38)/b18-15+/t25-,27+/m0/s1
InChI key
HZIRBXILQRLFIK-VPZZKNKNSA-N
一般描述
C6-NBD ceramide is a fluorescent labelled compound, known to be useful for the detection of enzymatic action. C6-NBD ceramide is preferred over radioactive compounds.
应用
C6-NBD Ceramide is suitable as a substrate for sphingomyelin synthase activity assay.
生化/生理作用
Sphingolipid metabolism yields ceramide as one of the products. The family of ceramide synthases catalyses its synthesis. The ceramides differ in its acyl chain length. Ceramides possess a wide range of functions, associated with apoptosis, cancer inhibition and chemotherapy. Its action is also related to neurodegenerative diseases.
包装
5 mL Amber Glass Screw Cap Vial (810209X-1mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
警示用语：
Danger
危险分类
Acute Tox. 3 Inhalation - Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 1 - STOT SE 3
靶器官
Central nervous system, Eyes,Central nervous system, Liver,Kidney
储存分类代码
3 - Flammable liquids
WGK
WGK 3
法规信息
危险化学品
易制毒化学品（2类）
Handbook of Glycosyltransferases and Related Genes, 5-5 (2011)
A role for ceramides, but not sphingomyelins, as antagonists of insulin signaling and mitochondrial metabolism in C2C12 myotubes
Park M, et al.
The Journal of Biological Chemistry, 291(46), 23978-23988 (2016)
Mammalian ceramide synthases
Levy M and Futerman AH
IUBMB Life, 62(5), 347-356 (2010)
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