质量水平
储存温度
−20°C
应用
NanoFabTx™ Synthetic Folate Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of folate-functionalized liposomes. This lipid mix enables users to encapsulate a wide variety of therapeutic drug molecules for targeted drug delivery applications without the need for lengthy trial-and-error optimization.
The NanoFabTx™ Synthetic Folate Lipid mix includes a lyophilized lipid blend containing rationally selected lipids that has been optimized to synthesize folate-functionalized liposomes of a desired size range. The synthesized folate-functionalized liposomes enable selectively targeting cells which overexpressed folate-receptors (e.g., HeLa cells) and delivery both hydrophilic and hydrophobic drugs.
The NanoFabTx™ Synthetic Folate Lipid mix includes a lyophilized lipid blend containing rationally selected lipids that has been optimized to synthesize folate-functionalized liposomes of a desired size range. The synthesized folate-functionalized liposomes enable selectively targeting cells which overexpressed folate-receptors (e.g., HeLa cells) and delivery both hydrophilic and hydrophobic drugs.
特点和优势
- A ready-to-use nanoformulation lipid blend for the synthesis of folate-functionalized liposomes
- Step-by-step extrusion and microfluidics protocols developed and tested by our formulation scientists
- Flexible synthesis methods to create uniform and reproducible liposomes
- Protocols and lipid blend optimized to synthesize liposomes around 100 nm with low polydispersity
- Lipid mix optimized for folate-functionalized liposomes for small molecule encapsulation
- A lipid film hydration and extrusion protocol
- A microfluidics protocol using commercial platforms or syringe pumps
法律信息
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
TMAX is a trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 3
法规信息
新产品
International journal of nanomedicine, 16, 683-700 (2021-02-05)
To develop an externally triggered rapid-release targeted system for treating ovarian cancer, gemcitabine (GMC) was entrapped into sonosensitive (SoS) folate (Fo)-modified liposomes (LPs). GMC-loaded LPs (GMC LPs), GMC-loaded Fo-targeted LPs (GMC-Fo LPs), and GMC-loaded Fo-targeted SoS LPs (GMC-SoS Fo LPs)
Pharmaceutical research, 36(8), 123-123 (2019-06-21)
This investigation was aimed to explore the targeting potential of folate conjugated double liposomes (fDLs) bearing combination of synergistic drugs (Prednisolone and Methotrexate) for effective management of the rheumatoid arthritis (RA). To overcome the drawbacks of monotherapy, a combination of
International journal of nanomedicine, 14, 6249-6268 (2019-09-10)
To develop an intravesical instillation system for the treatment of bladder cancer, rapamycin (Rap) was encapsulated into liposomes and then homogeneously dispersed throughout a poloxamer 407 (P407)-based hydrogel. Rap-loaded conventional liposomes (R-CL) and folate-modified liposomes (R-FL) were prepared using a
Signal transduction and targeted therapy, 5(1), 6-6 (2020-04-17)
Tumor-associated macrophages (TAMs) facilitate cancer progression by promoting tumor invasion, angiogenesis, metastasis, inflammatory responses, and immunosuppression. Folate receptor β (FRβ) is overexpressed in TAMs. However, the clinical significance of FRβ-positive macrophages in lung cancer remains poorly understood. In this study
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