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Merck
CN
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文件

安全信息

900744

Sigma-Aldrich

TMS-N-ethynyl-N,4-dimethylbenzenesulfonamide

≥95%

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别名:
N,4-Dimethyl-N-((trimethylsilyl)ethynyl)benzenesulfonamide, TMS-N-methylynetoluenesulfonamide, TMS-MTYsA
经验公式（希尔记法）:
C13H19NO2SSi
分子量:
281.45
UNSPSC代码:
12352200

检测方案

≥95%

形式

solid

mp

55 °C

储存温度

2-8°C

SMILES字符串

CC1=CC=C(S(=O)(N(C)C#C[Si](C)(C)C)=O)C=C1

应用

TMS-N-ethynyl-N,4-dimethylbenzenesulfonamide (TMS-MTYsA) is an air- and moisture-stable ynamide demonstrated to be an efficient and high-yielding coupling reagent for selective amide and peptide bond formation under mild reaction conditions without racemization. The product is supplied as the TMS-protected ynamide, which can be easily deprotected in situ without isolating the product.

其他说明

Ynamides as Racemization-Free Coupling Reagents for Amide and Peptide Synthesis

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Enantioselective synthesis of β-amino acid derivatives via nickel-promoted regioselective carboxylation of ynamides and rhodium-catalyzed asymmetric hydrogenation.
Saito N, et al.
Organic & Biomolecular Chemistry, 14(42), 10080-10089 (2016)
Regio-and Stereoselective Synthesis of 2-Amino-1, 3-diene Derivatives by Ruthenium-Catalyzed Coupling of Ynamides and Ethylene.
Saito N, et al.
Organic Letters, 13(10), 2718-2721 (2011)
Gold-Catalyzed Intermolecular Nitrene Transfer from 2 H-Azirines to Ynamides: A Direct Approach to Polysubstituted Pyrroles.
Zhu L, et al.
Organic Letters, 17(1), 30-33 (2014)
Ynamides as Racemization-Free Coupling Reagents for Amide and Peptide Synthesis.
Hu L, et al.
Journal of the American Chemical Society, 138(40), 13135-13138 (2016)

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