D125407
N,N′-二异丙基碳二亚胺
99%, for peptide synthesis
别名:
N,N′-二异丙基碳二亚胺
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关于此项目
线性分子式:
(CH3)2CHN=C=NCH(CH3)2
化学文摘社编号:
分子量:
126.20
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352111
EC Number:
211-743-7
MDL number:
Beilstein/REAXYS Number:
878281
产品名称
N,N′-二异丙基碳二亚胺, 99%
InChI key
BDNKZNFMNDZQMI-UHFFFAOYSA-N
InChI
1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3
SMILES string
CC(C)N=C=NC(C)C
assay
99%
form
liquid
reaction suitability
reaction type: Coupling Reactions
refractive index
n20/D 1.433 (lit.)
bp
145-148 °C (lit.)
density
0.815 g/mL at 20 °C (lit.)
application(s)
peptide synthesis
Quality Level
Gene Information
human ... EPHX2(2053)
mouse ... Ephx2(13850)
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Application
DIC（N,N′-二异丙基碳二亚胺）已与1-羟基-7-阿扎苯并三唑(HOAt)联用，从而将氨基酸与N-烯丙基甘氨酸偶联形成N-烯丙基肽。
替代肽合成中的二环己基碳二亚胺。
肽合成的偶联剂。
General description
DIC为N,N′-二异丙基碳二亚胺的缩写。它参与N-(β-羟基)酰胺的环化反应，形成2-恶唑啉。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Inhalation - Eye Dam. 1 - Flam. Liq. 3 - Resp. Sens. 1 - Skin Sens. 1
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
91.4 °F
flash_point_c
33 °C
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
非剧毒-急性毒性1
危险化学品
此项目有
Collection of Czechoslovak Chemical Communications, 59, 691-691 (1994)
Tetrahedron Letters, 35, 5981-5981 (1994)
Cody L Gilleland et al.
Genetics, 201(1), 39-46 (2015-07-15)
A major goal in the study of human diseases is to assign functions to genes or genetic variants. The model organism Caenorhabditis elegans provides a powerful tool because homologs of many human genes are identifiable, and large collections of genetic
Synthesis of 2-oxazolines mediated by N,N'-diisopropylcarbodiimide.
Crosignani S, et al.
Tetrahedron Letters, 45(52), 9611-9615 (2004)
P J Weber et al.
Bioorganic & medicinal chemistry letters, 8(6), 597-600 (1999-01-01)
A new method has been developed to synthesize fluorescein labeled peptides, compounds of increasing importance in bioorganic chemistry, cell biology, pharmacology, drug targeting and medicinal chemistry. We show, that 4(5)-carboxyfluorescein is much more efficient than the hitherto predominantly utilized reagents
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