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Merck
CN

763896

Sigma-Aldrich

DL-α-生育酚甲氧基聚乙二醇琥珀酸酯

greener alternative

别名:

TPGS-750-M

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About This Item

UNSPSC代码:
51171641
NACRES:
NA.22

形式

powder

质量水平

反应适用性

reagent type: catalyst
reaction type: C-H Activation

reagent type: surfactant

环保替代产品特性

Catalysis
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

转变温度

Tm 29-34

环保替代产品分类

一般描述

我们致力于为您带来更加绿色的替代产品,这些产品遵守一项或多项绿色化学12项原则。本品(TPGS-750-M) 是许多过渡金属催化交叉偶联反应采用的主要表面活性剂,已强化催化效率。点击此处,查看更多详情。
要了解更多信息,请访问Bruce Lipshutz教授的教授和产品门户网站

应用

DL-α-生育酚甲氧基聚乙二醇琥珀酸酯(TPGS-750-M)是天然维生素E的可生物降解和水溶性衍生物,在水中金属催化的交叉偶联反应中用作环境良性非离子表面活性剂。它用于Heck、Suzuki-Miyaura、Sonogashira和Negishi之类的偶联反应。它也可用于胺化、C-H活化和烯烃复分解反应。
TPGS-750-M也可用于:
  • 芳基和杂芳基卤化物与氮、氧、硫亲核试剂在温和条件下的亲核芳香取代反应。
  • 喹喔啉酮经C(sp2)羟化反应制取喹喔啉-2,3二酮。
  • 使用铜催化剂的胺的分子内N-芳基化。

其他说明

观看 Lipshutz 教授在本次网络研讨会上谈论 TPGS-750-M:
从毫克到公斤:遵循自然引导的合成化学′

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价格

闪点(°F)

Not applicable

闪点(°C)

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分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Application of nanoparticle mediated N-arylation of amines for the synthesis of pharmaceutical entities using vit-E analogues as amphiphiles in water
Kumar A and Bishnoi AK
Royal Society of Chemistry Advances, 5(26), 20516-20520 (2015)
Metal-Free C3 Hydroxylation of Quinoxalin-2 (1H)-ones in Water
Peng S, et al.
Advanced Synthesis & Catalysis, 361(24), 5721-5726 (2019)
Metal-Free C3 Hydroxylation of Quinoxalin-2 (1H)-ones in Water
Peng S, et al.
advanced synthesis and catalysis, 361(24), 5721-5726 (2019)
TPGS-750-M: a second-generation amphiphile for metal-catalyzed cross-couplings in water at room temperature
Lipshutz BH, et al.
The Journal of Organic Chemistry, 76(11), 4379-4391 (2011)
Nucleophilic aromatic substitution reactions in water enabled by micellar catalysis
Isley NA, et al.
Organic Letters, 17(19), 4734-4737 (2015)

商品

Lipshutz及其同事最近开发了第二代技术,用于基于聚氧乙戊基-α-生育酚琥珀酸酯衍生物TPGS-750-M的原始PTS表面活性剂。

Micellular catalysis has provided the ability to carry out several commonly used transformations used in the synthetic community to be carried out in water.

Lipshutz and co-workers have recently developed a second generation technology to their original PTS-enabling surfactant based on the polyoxyethanyl-α-tocopheryl succinate derivative, TPGS-750-M.

Surfactants for efficient reactions in water as a green chemistry alternative.

实验方案

TPGS-750-M surfactant enables various reactions in water at room temperature, enhancing efficiency and versatility in synthesis.

相关内容

Prof. Bruce Lipshutz and co-workers have developed designer surfactants to allow several classes of transformations (e.g. Suzuki-Miyaura, Olefin Metathesis, 1,4-Addition to Enones, etc.) to be performed in water.

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

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