推荐产品
质量水平
检测方案
96%
形式
solid
旋光性
[α]20/D -9.0°, c = 1 in methanol
mp
253-258 °C
SMILES字符串
C1CN[C@@H](C1)c2nnn[nH]2
InChI
1S/C5H9N5/c1-2-4(6-3-1)5-7-9-10-8-5/h4,6H,1-3H2,(H,7,8,9,10)/t4-/m0/s1
InChI key
XUHYQIQIENDJER-BYPYZUCNSA-N
应用
(S)-(−)-5-(2-Pyrrolidinyl)-1H-tetrazole can be used as an organocatalyst:
- To prepare enantioselective chiral 1,2-oxazines from achiral ketones via an intramolecular Wittig reaction.
- To synthesize diastereoselective Michael addition products by addition of aliphatic aldehydes to β-nitrostyrene.
- In the direct asymmetric α-fluorination of linear and branched aldehydes using N-fluorobenzenesulfonamide as the fluorinating agent.
Organocatalyst used for:
- Direct asymmetric aldol reactions between acetone and aldehydes yielding β -hydroxy ketone and for synthesizing 1,1,1-trichloro-2-alkanols
- Mannich reactions for synthesis fo α -amino acids and generation of 1,4-diamines
- Conjugate additions of malonates to enones
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Oelke, A. et al.
Synlett, 2548-2548 (2006)
Sirirat Kumarn et al.
Chemical communications (Cambridge, England), (30), 3211-3213 (2006-10-10)
A sequential, organocatalysed asymmetric reaction to access chiral 1,2-oxazines from achiral ketone starting materials is reported, which proceeds in moderate to good yields and excellent enantioselectivity.
Direct asymmetric α-fluorination of aldehydes
Steiner DD, et al.
Angewandte Chemie (International Edition in English), 117(24), 3772-3776 (2005)
A highly selective, organocatalytic route to chiral 1, 2-oxazines from ketones
Kumarn S, et al.
Chemical Communications (Cambridge, England), 3211-3213 (2006)
Asymmetric organocatalyzed Michael addition of aldehydes to β-nitrostyrene in ionic liquids
Mevciarova M, et al.
Tetrahedron Asymmetry, 20(20), 2403-2406 (2009)
相关内容
The Yamamoto group has employed several applications in catalysis.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门