跳转至内容
Merck
CN
所有图片(6)

文件

G8877

Sigma-Aldrich

鸟苷5′-三磷酸 钠盐 水合物

≥95% (HPLC), powder

登录查看公司和协议定价
所有图片(6)
别名:
GTP
经验公式（希尔记法）:
C10H16N5O14P3 · xNa+
CAS号:
36051-31-7
分子量:
523.18 (free acid basis)
Beilstein:
3585677
EC 号:
252-847-2
MDL编号:
MFCD00077781
UNSPSC代码:
41106305
PubChem化学物质编号:
24895354
NACRES:
NA.77

质量水平

200

检测方案

≥95% (HPLC)

形式

powder

颜色

white

溶解性

H2O: 50 mg/mL

运输

dry ice

储存温度

−20°C

SMILES字符串

[Na+].[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H16N5O14P3.3Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);;;/q;3*+1/p-3/t3-,5-,6-,9-;;;/m1.../s1

InChI key

KZRMTEVIDYXWQW-CYCLDIHTSA-K

基因信息

human ... HRAS(3265)

正在寻找类似产品? 访问 产品对比指南

相关类别

应用

鸟苷5′-三磷酸钠盐水合物已用于：
  • 辣根过氧化物酶（HRP）修饰的平板试剂制备
  • 全细胞电压钳记录
  • 转谷氨酰胺酶（tTG）的体外抑制

生化/生理作用

GTP可用作参与到将化学能导入至特定的生物合成途径的磷酸酶和焦磷酸酶载体。GTP可将参与到包括增殖、分化等多种细胞过程的信号转导G蛋白进行激活，以及多种细胞间激酶级联反应的激活。增殖和凋亡是部分受到由小GTPase Ras和Rho介导的GTP水解调控的。另一种类型的小GTPase，Rab可在囊泡的对接和融合中起到作用，并也可能参与到囊泡的形成。除了在信号转导中发挥作用外，GTP还可在DNA和RNA的酶促生物合成中作为单核苷酸单位的富含能量前体。

特点和优势

该化合物是环状核苷酸研究的特色产品。点击此处以发现更多的环状核苷酸特色产品。可访问sigma.com/discover-bsm了解更多关于用于其他研究领域生物活性小分子。

制备说明

由5′-GMP的酶促磷酸化而制备。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type N95 (US)

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

T cells from celiac disease lesions recognize gliadin epitopes deamidated in situ by endogenous tissue transglutaminase
Molberg O, et al.
European Journal of Immunology, 31(5), 1317-1323 (2001)
Flufenamic acid affects multiple currents and causes intracellular Ca2+ release in Aplysia bag cell neurons
Gardam K E, et al.
Journal of Neurophysiology, 100(1), 38-49 (2008)
Feng Rao et al.
Analytical biochemistry, 389(2), 138-142 (2009-03-31)
The cyclic dinucleotide c-di-GMP is a widespread bacterial messenger molecule with potential application as a therapeutic agent for treating bacterial infection. Current enzymatic synthesis of c-di-GMP using mesophilic diguanylate cyclase (DGC) proteins suffers from low production yield due to protein
Rob P M van Gijlswijk et al.
Clinical chemistry, 48(8), 1352-1359 (2002-07-27)
Microarray platforms will change immunochemical and nucleic acid-based analysis of cell homogenates and body fluids compared with classic analyses. Microarrays use labeled target and immobilized probes, rather than fixed targets and labeled probes. We describe a method for simultaneous labeling
M Uriarte et al.
The Biochemical journal, 293 ( Pt 1), 93-100 (1993-07-01)
A glycoprotein fraction was isolated from rat liver membranes by affinity chromatography on immobilized wheat-germ lectin. Incubation of this fraction with MgATP or MgGTP resulted in a sequential phosphorylation and dephosphorylation of a complex of three polypeptides (118, 128 and
查看所有相关文献

商品

Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

实验方案

HPLC Analysis of GMP, GDP and GTP on SeQuant ZIC-HILIC

HPLC Analysis of GMP, GDP and GTP on SeQuant ZIC-HILIC

LC/MS Analysis of Nucleotides SeQuant® ZIC®-cHILIC – Effect of pH

ZIC®-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.

LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门