88185
四唑 溶液
~0.45 M in acetonitrile, solution, suitable for DNA synthesis, filtered through a 1 μm filter
别名:
1H-Tetrazole
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关于此项目
经验公式（希尔记法）:
CH2N4
化学文摘社编号:
分子量:
70.05
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Beilstein/REAXYS Number:
105799
Technique(s):
DNA synthesis: suitable
Bp:
84 °C (lit.)
产品名称
四唑 溶液, suitable for DNA synthesis, filtered through a 1 μm filter, ~0.45 M in acetonitrile
InChI
1S/CH2N4/c1-2-4-5-3-1/h1H,(H,2,3,4,5)
SMILES string
c1nnn[nH]1
InChI key
KJUGUADJHNHALS-UHFFFAOYSA-N
form
liquid
quality
filtered through a 1 μm filter
concentration
~0.45 M in acetonitrile
technique(s)
DNA synthesis: suitable
impurities
≤0.003% water
bp
84 °C (lit.)
mp
156-158 °C (lit.)
density
0.798 g/mL at 20 °C
Quality Level
General description
本品为约 0.45M 四唑乙腈溶液。四唑环在各种合成和工业生产过程中起重要的作用。
Application
四唑溶液可用于 DNA 合成。它可用作在原位 合成脱氧核苷亚磷酰胺的催化剂。可用于制备以下阴离子核苷酸脂质：
- 胸苷 3′-（1,2-二苯甲酰- 锡 -甘油-3-磷酸），diC 12 -3′-dT
- 胸苷 3′-（1,2-二肉豆蔻酰- 锡 -甘油-3-磷酸）diC 14 -3′-dT
- 胸苷-3′-（1,2-二棕榈酰- 锡 -甘油-3-磷酸）diC 16 -3′-dT
Other Notes
寡核苷酸亚磷酸三酯法合成（二烷基氨基）膦偶联用催化剂
Disclaimer
室温下为饱和溶液；低于室温储存会产生沉淀。
signalword
Danger
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
存储类别
3 - Flammable liquids
wgk
WGK 3
flash_point_f
41.0 °F - closed cup
flash_point_c
5 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
危险化学品
此项目有
Azidoazomethine-tetrazole isomerism in solution: A thermochemical study.
Cubero E, et al.
The Journal of Organic Chemistry, 63(7), 2354-2356 (1998)
Salim Khiati et al.
Bioconjugate chemistry, 20(9), 1765-1772 (2009-08-29)
A family of new anionic nucleotide based lipids featuring thymidine-3'-monophosphate as nucleotide and 1,2-diacyl-sn-glycerol as lipid moiety for in vitro delivery of nucleic acids is described. The nucleotide lipids were prepared in three steps starting from 1,2-diacyl-sn-glycerols and 2'-deoxythymidine-3'-phosphoramidite. Gel
A D Barone et al.
Nucleic acids research, 12(10), 4051-4061 (1984-05-25)
Deoxynucleoside phosphoramidites can be prepared in good yield from deoxynucleosides, bis- dialkylaminophosphines , and the corresponding dialkylamine hydrotetrazolide or tetrazole as catalysts. These phosphoramidites generated in situ lead to the direct synthesis of deoxyoligonucleotides on polymer supports.
Falgun Shah et al.
Journal of chemical information and modeling, 52(3), 696-710 (2012-02-16)
Falcipains (FPs) are hemoglobinases of Plasmodium falciparum that are validated targets for the development of antimalarial chemotherapy. A combined ligand- and structure-based virtual screening of commercial databases was performed to identify structural analogs of virtual screening hits previously discovered in
J Nielsen et al.
Nucleic acids research, 14(18), 7391-7403 (1986-09-25)
Deoxyribonucleoside phosphoramidites are prepared in situ from 5'-O,N-protected deoxyribonucleosides and 2-cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite with tetrazole as catalyst, and the solutions applied directly on an automatic solid-phase DNA synthesizer. Using LCAA-CPG support and a cycle time of 12.5 min, oligonucleotides of 16-25
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