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Merck
CN
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文件

342122

Sigma-Aldrich

1-甲基-3-硝基胍

contains ~25% water

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线性分子式:
CH3NHC(=NH)NHNO2
CAS号:
4245-76-5
分子量:
118.09
MDL编号:
MFCD00024167
UNSPSC代码:
12352100
PubChem化学物质编号:
24861030

形式

solid

质量水平

100

包含

~25% water

mp

153-155 °C (lit.)

SMILES字符串

CNC(=N)N[N+]([O-])=O

InChI

1S/C2H6N4O2/c1-4-2(3)5-6(7)8/h1H3,(H3,3,4,5)

InChI key

XCXKNNGWSDYMMS-UHFFFAOYSA-N

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一般描述

在黄嘌呤氧化酶系统中，1-甲基-3-硝基-1-亚硝基胍 (MNG) 诱发胃癌的过程中，MNG 作为中间产物生成羟基自由基。美国空军武器实验室已将 MNG 用于爆炸物配方。MNG 是在 H2O2 对 MNNG 的亚硝基氮进行亲核进攻过程中形成的。MNG 是 N -甲基- N′ 的非致癌性类似物-硝基- N -亚硝基胍（直接作用的致癌物）。

应用

1-甲基-3-硝基胍（ N -甲基- N′-硝基胍）用于氯噻尼定半抗原的合成。

象形图

FlameExclamation mark
GHS02,GHS07

警示用语：

Danger

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Sol. 1 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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The viable but nonculturable (VBNC) suppression mutant formed platable cells at low temperature stress after inoculation in artificial seawater (ASW). Suppression subtractive hybridization was used to identify differentially expressed genes among cDNAs of the VBNC suppression mutant and the wild-type
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Free radical research, 36(6), 641-647 (2002-08-16)
We have examined the mechanism of 1-methyl-3-nitro-1-nitrosoguanidine (MNNG)-induced gastric cancer with respect to the production of hydroxyl free radical (OH). Nucleophilic attack by H2O2 on the nitroso group of MNNG produces 1-methyl-3-nitroguanidine (MNG) and the intermediate peroxynitric acid (ONOOH), which
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Currently, N-methyl-N'-nitroguanidine (MNG) is being considered by the U.S. Air Force Armament Laboratory for use in explosive formulations. A mammalian toxicity profile has been performed which includes the analysis of chemical impurities and an assessment of the potential for the
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Previously, we have shown that Chinese hamster ovary (CHO) cells are useful for quantifying chemical-induced gene mutations. We have defined the conditions of a Multiplex CHO System which permits determination of mutagen-induced chromosome aberration, and sister chromatid exchange (SCE) in
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Neonicotinoids (NNs), a widely used class of systemic pesticides, are regarded as exhibiting selective toxicity in insects. However, NNs are suspected of exerting adverse effects on mammals as well, including humans. To date, only adult male animal models have been
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