一般描述
7,12-二甲基苯并[a]蒽属于多环芳烃类物质。它是一种由汽油和煤的不完全燃烧产生的致癌性有机污染物。
应用
7,12-二甲基苯并[a]蒽用于：
- 研究黑升麻(CR)提取物对7,12-二甲基苯并[a]蒽诱导的哺乳动物肿瘤生长的影响
- 作为启动剂诱发CD-1小鼠模型的皮肤癌，用于进行4种红酒多酚的抗癌特性比较
- 诱发上皮细胞癌变，以便研究叙利亚仓鼠颊囊的正常、增生、发育不良和恶性口腔上皮细胞的凋亡、增殖和p12doc-1特性
- 诱发乳腺肿瘤，用于探究大鼠肝脏中他莫昔芬引起的三酰甘油积聚的成因和预防
生化/生理作用
7,12-二甲基苯并[a]蒽具有细胞毒性，属于致癌物质。它可造成肾上腺的选择性坏死和出血，并对血浆碱性磷酸酶水平具有抑制作用。这些伤害作用都是因为它能通过将电子供给适合的电子受体，形成电荷转移复合物。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Carc. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
个人防护装备
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