N4766
N-亚硝基-N-甲基脲
Bulk package
别名:
MNU, N-甲基-N-亚硝基脲
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关于此项目
经验公式（希尔记法）:
C2H5N3O2
化学文摘社编号:
分子量:
103.08
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
Form:
solid
InChI
1S/C2H5N3O2/c1-5(4-7)2(3)6/h1H3,(H2,3,6)
SMILES string
CN(N=O)C(N)=O
InChI key
ZRKWMRDKSOPRRS-UHFFFAOYSA-N
form
solid
contains
aqueous acetic acid as stabilizer
storage temp.
2-8°C
Biochem/physiol Actions
一种在许多动物物种中具有致癌性的DNA烷基化剂。 尽管MNU可以在大多数器官中诱发良性和恶性肿瘤，但它最常用于模拟乳腺肿瘤的发生和发展。
Packaging
Weight on dry basis.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Carc. 1B - Flam. Sol. 2 - Repr. 1B
存储类别
4.1B - Flammable solid hazardous materials
wgk
WGK 1
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges
法规信息
监管及禁止进口产品
此项目有
Yong Soon Chun et al.
Carcinogenesis, 33(11), 2242-2249 (2012-07-27)
Multiple lines of evidence support a role for curcumin in cancer chemoprevention. Nonetheless, despite its reported efficacy and safety profile, clinical translation of curcumin has been hampered by low oral bioavailability, requiring infeasible 'mega' doses for achieving detectable tissue levels.
Marzena Kurowska et al.
Mutation research, 738-739, 52-70 (2012-10-23)
We present studies aimed at determining the types and frequencies of mutations induced in the barley genome after treatment with chemical (N-methyl-N-nitrosourea, MNU) and physical (gamma rays) mutagens. We created M(2) populations of a doubled haploid line and used them
Alice A Ramos et al.
Journal of toxicology and environmental health. Part A, 75(13-15), 765-775 (2012-07-14)
DNA damage induced by oxidative and alkylating agents contributes to carcinogenesis, leading to possible mutations if replication proceeds without proper repair. However, some alkylating agents are used in cancer therapy due to their ability to induce DNA damage and subsequently
Kawiya Sintara et al.
Journal of biomedicine & biotechnology, 2012, 915380-915380 (2012-06-13)
To determine effects of curcumin on N-methyl-N-nitrosourea (MNU) and saturated sodium chloride (s-NaCl)-induced gastric cancer in rats. Male Wistar rats were divided into 5 groups: control (CO), control supplemented with 200 mg/kg curcumin (CC), MNU + s-NaCl, MNU + s-NaCl supplemented with 200 mg/kg curcumin daily
Bianca F Gonçalves et al.
The Prostate, 73(11), 1202-1213 (2013-04-27)
Characterization of novel rodent models for prostate cancer studies requires evaluation of either spontaneous and carcinogen-induced tumors as well as tumor incidence in different prostatic lobes. We propose a new short-term rodent model of chemically induced prostate carcinogenesis in which
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