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Merck
CN
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文件

318434

Sigma-Aldrich

3,3′-二丙基硫杂羰花青碘化物

98%

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别名:
3-Propyl-2-[3-[3-propyl-2(3H)benzothiazolylidene]-1-propenyl]benzothiazolium iodide, DiSC3(3)
经验公式（希尔记法）:
C23H25IN2S2
CAS号:
53336-12-2
分子量:
520.49
Beilstein:
3842440
MDL编号:
MFCD00013340
UNSPSC代码:
12171500
PubChem化学物质编号:
329753928
NACRES:
NA.47

检测方案

98%

形式

crystalline powder

mp

288 °C (dec.) (lit.)

溶解性

chloroform/methanol: 10 mg/mL, clear

λmax

559 nm

ε (消光系数)

163120 at 599 nm in methanol at 0.00463 g/L
17425 at 298 nm in methanol at 0.00463 g/L
40246 at 220 nm in methanol at 0.00463 g/L

荧光

λex 559 nm; λem 575 nm in methanol

应用

diagnostic assay manufacturing
hematology
histology

储存温度

room temp

SMILES字符串

[I-].CCCN1C(\Sc2ccccc12)=C\C=C\c3sc4ccccc4[n+]3CCC

InChI

1S/C23H25N2S2.HI/c1-3-16-24-18-10-5-7-12-20(18)26-22(24)14-9-15-23-25(17-4-2)19-11-6-8-13-21(19)27-23;/h5-15H,3-4,16-17H2,1-2H3;1H/q+1;/p-1

InChI key

JGTCEHAVVINOPG-UHFFFAOYSA-M

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相关类别

一般描述

3,3′-Dipropylthiacarbocyanine iodide is a carbocyanine fluorescent dye sensitive to membrane potential. This cyanine dye plays a vital role as an optical probe of membrane potential. An increase in the fluorescence intensity of the dye indicates depolarization of the plasma membrane potential.

应用

3,3′-Dipropylthiacarbocyanine iodide has been used to determine bacterial membrane permeability by the effect of electrochemical scaffold treatment.

生化/生理作用

The embrane potential sensitive dye, 3,3′dipropylthiacarbocyanine iodide enters only depolarized cells, where it binds reversibly to lipid-rich intracellular components.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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Baozhen Qu et al.
Molecular immunology, 127, 57-66 (2020-09-15)
Conventional role of ribosomal proteins is ribosome assembly and protein translation, but some ribosomal proteins also show antimicrobial peptide (AMP) activity, though their mode of action remains ill-defined. Here we demonstrated for the first time that amphioxus RPS15, BjRPS15, was
Yashuo Wang et al.
Fish & shellfish immunology, 77, 100-111 (2018-03-24)
The ever-growing concerns on multi-drug resistant (MDR) bacteria lead to urgent demands for novel antibiotics including antimicrobial peptides (AMPs). Pt5, a peptide consisting of the C-terminal 55 residues of zebrafish phosvitin, has been shown to function as an antibacterial agent.
Zengyu Ma et al.
Developmental and comparative immunology, 110, 103730-103730 (2020-05-20)
Previous studies show that some ribosomal proteins possess antimicrobial peptide (AMP) activity. However, information as such remains rather fragmentary and rather limited. We showed here for the first time that amphioxus RPS23, BjRPS23, was a previously uncharacterized AMP. It not
Marie Kodedová et al.
Biochimica et biophysica acta, 1859(10), 1851-1858 (2017-06-11)
We compared the potency of four derivatives of the antimicrobial peptide halictine-2 against six Candida species. Observed activity was peptide and species specific. Halictines rapidly permeabilized cell membranes and caused the leakage of cytosolic components. Their killing potential was enhanced
Toshihiko Kinjo et al.
Neurochemical research, 43(1), 70-79 (2017-06-14)
Mitochondrial permeability transition pore (PTP) is supposed to at least in part participate in molecular mechanisms underlying the neurotoxicity seen after overactivation of N-methyl-D-aspartate (NMDA) receptor (NMDAR) in neurons. In this study, we have evaluated whether activation of GABA
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