InChI key
FFGPTBGBLSHEPO-UHFFFAOYSA-N
InChI
1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)
SMILES string
NC(=O)N1c2ccccc2C=Cc3ccccc13
assay
99%
mp
191-192 °C (lit.)
Gene Information
human ... SCN5A(6331)
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Biochem/physiol Actions
抗惊厥药；GABAA受体苯二氮卓调节位点的配体。钠离子通道抑制剂。
法规信息
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Sjors H W Schulpen et al.
Toxicological sciences : an official journal of the Society of Toxicology, 146(2), 311-320 (2015-05-17)
Differentiating pluripotent stem cells in vitro have proven useful for the study of developmental toxicity. Here, we studied the effects of anticonvulsant drug exposure in a human embryonic stem cell (hESC)-based neurodevelopmental toxicity test (hESTn). During neural differentiation the cells were
Simon Komtchou et al.
Environmental science and pollution research international, 22(15), 11513-11525 (2015-04-01)
The electrochemical degradation of carbamazepine (CBZ) in both synthetic solutions (CBZo = 12 mg/L) and enriched municipal effluents (CBZo = 60-70 μg/L) was investigated using an electro-Fenton (EF) process. Different operating parameters were investigated, including current intensity, pH, reaction time, ferrous ion concentration, and
Emilie Lacaze et al.
Environmental pollution (Barking, Essex : 1987), 202, 177-186 (2015-04-02)
The potential toxicity of pharmaceuticals towards aquatic invertebrates is still poorly understood and sometimes controversial. This study aims to document the in vitro genotoxicity and immunotoxicity of psychotropic drugs and antibiotics on Mytilus edulis. Mussel hemocytes were exposed to fluoxetine, paroxetine
Julia Rossmann et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1000, 84-94 (2015-07-27)
Matrix effects that occur during quantitative measurement by liquid chromatography mass spectrometry specifically when using electrospray ionization are a widely recognized phenomenon. Sample matrix compounds affect the ionization process of the target analytes, lead to a low signal response, and
A high throughput screening system for predicting chemically-induced reproductive organ deformities.
Bart van der Burg et al.
Reproductive toxicology (Elmsford, N.Y.), 55, 95-103 (2014-12-22)
There is a great need for alternative testing methods for reproductive toxicants that are practical, fast, cost-effective and easy to interpret. Previously we followed a pragmatic approach using readily available tests, which was successful in predicting reproductive toxicity of chemicals
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