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Gram-positive antimicrobial activity of amino acid-based hydrogels.

Gram-positive antimicrobial activity of amino acid-based hydrogels.

Advanced materials (Deerfield Beach, Fla.) (2014-12-03)

I Irwansyah, Yong-Qiang Li, Wenxiong Shi, Dianpeng Qi, Wan Ru Leow, Mark B Y Tang, Shuzhou Li, Xiaodong Chen

ABSTRACT

Antimicrobial hydrogels are prepared based on the co-assembly of commercial Fmoc-phenylalanine and Fmoc-leucine, which act as the hydrogelator and antimicrobial building block, respectively. This co-assembled antimicrobial hydrogel is demonstrated to exhibit selective bactericidal activity for gram-positive bacteria while being biocompatible with normal mammalian cells, showing great potential as an antimicrobial coating for clinical anti-infective applications.

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