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G7776

Sigma-Aldrich

Glutaraldehyde solution

Grade I, 70% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use

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Synonym(s):
Glutaric dialdehyde solution, Pentane-1,5-dial
Linear Formula:
OHC(CH2)3CHO
CAS Number:
111-30-8
Molecular Weight:
100.12
Beilstein:
605390
MDL number:
MFCD00007025
UNSPSC Code:
12352114
PubChem Substance ID:
24895322
NACRES:
NA.21

Quality Level

200

type

Grade I

form

liquid

concentration

70% in H2O

technique(s)

electron microscopy: suitable (fixative)

color

colorless

solubility

water: soluble

storage temp.

−20°C

SMILES string

[H]C(CCCC([H])=O)=O

InChI

1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2

InChI key

SXRSQZLOMIGNAQ-UHFFFAOYSA-N

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General description

Glutaraldehyde is a fixative used in electron microscopy. It is a rapidly penetrating fixative and an alternative to the expensive and toxic buffered osmium tetroxide. Glutaraldehyde contains two aldehyde group separated by three methylene bridges. It mediates protein crosslinking at their amino groups.

Application

Glutaraldehyde solution has been used as a fixative for transfected adherent monkey kidney fibroblasts (COS-7) cells for electron microscopy studies, human osteosarcoma (U2OS) cells for super-resolution (SR) experiments and for hydrogels for scanning electron microscopy (SEM) studies.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Supplementary Hazards

EUH071

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品

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BRCA2 controls DNA: RNA hybrid level at DSBs by mediating RNase H2 recruitment
D?Alessandro G, et al.
Nature Communications, 9(1), 5376-5376 (2018)
Formaldehyde, formalin, paraformaldehyde and glutaraldehyde: what they are and what they do
Kiernan JA
Microscopy today, 8(1), 8-13 (2000)
Poly (Ethylene Glycol)-Crosslinked gelatin hydrogel substrates with conjugated bioactive peptides influence endothelial cell behavior
Su J, et al.
Biomaterials, 201(1), 99-112 (2019)
Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy
Schessl J, et al.
The Journal of Clinical Investigation, 118(3), 904-912 (2008)
Ming Fang et al.
BMC neuroscience, 16, 84-84 (2015-11-27)
Scutellarin, an anti-inflammatory agent, effectively suppressed microglia activation in rats with middle cerebral artery occlusion (MCAO). Robust microglia activation, acute in onset, was followed by astrogliosis. This study was aimed to determine if scutellarin would also affect the reactive astrocytes
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