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P4170

Sigma-Aldrich

Propidium iodide

≥94.0% (HPLC)

Synonym(s):

3,8-Diamino-5-[3-(diethylmethylammonio)propyl]-6-phenylphenanthridinium diiodide

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100 MG
¥3,795.88

¥3,795.88

Available to ship on2025年4月27日Details

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100 MG
¥3,795.88

About This Item

Empirical Formula (Hill Notation):
C27H34I2N4
CAS Number:
25535-16-4
Molecular Weight:
668.39
Beilstein:
3843838
EC Number:
247-081-0
MDL number:
MFCD00011921
UNSPSC Code:
41106305
PubChem Substance ID:
57654524
NACRES:
NA.77

¥3,795.88

Available to ship on2025年4月27日Details

Request a Bulk Order

Quality Level

200

Assay

≥94.0% (HPLC)

form

powder

mp

220-225 °C (dec.) (lit.)

storage temp.

2-8°C

SMILES string

[I-].[I-].CC[N+](C)(CC)CCC[n+]1c(-c2ccccc2)c3cc(N)ccc3c4ccc(N)cc14

InChI

1S/C27H33N4.2HI/c1-4-31(3,5-2)17-9-16-30-26-19-22(29)13-15-24(26)23-14-12-21(28)18-25(23)27(30)20-10-7-6-8-11-20;;/h6-8,10-15,18-19,29H,4-5,9,16-17,28H2,1-3H3;2*1H/q+1;;/p-1

InChI key

XJMOSONTPMZWPB-UHFFFAOYSA-M

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This Item
PHR220908511239802
Curcumin suitable for matrix substance for MALDI-MS, ≥99.5% (HPLC)

78246

Curcumin

Curcumin Pharmaceutical Secondary Standard; Certified Reference Material

PHR2209

Curcumin

Curcumin analytical standard

08511

Curcumin

Curcumin, Curcuma longa L. A cell-permeable and irreversible antitumor and anti-inflammatory agent that acts as an inhibitor of 5-lipoxygenase (IC₅₀ = 8 µM) and cyclooxygenase (IC₅₀ = 52 µM).

239802

Curcumin, Curcuma longa L.

assay

≥99.5% (HPLC)

assay

-

assay

≥98.0% (HPLC)

assay

≥80% (HPLC)

form

powder

form

solid

form

powder

form

solid

Quality Level

100

Quality Level

300

Quality Level

100

Quality Level

100

technique(s)

MALDI-MS: suitable

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

storage temp.

2-8°C

storage temp.

-10 to -25°C

storage temp.

2-8°C

storage temp.

10-30°C

grade

matrix substance for MALDI-MS

grade

certified reference material, pharmaceutical secondary standard

grade

analytical standard

grade

-

General description

Propidium iodide (PI) is a fluorescent dye thatcan be used for staining nucleic acids.[1] It is impermeable in viable orintact cells. It can penetrate easily into dead, dying, or membrane-compromisedcells.[1][2] PI has the capacity to bind easily to DNA.[3]

Application

Propidiumiodide has been used: to detect cell cycle by flow cytometry and γH2AXand pH3 analysis[4],apoptosis assay in hepatic stellate cells (HSCs)[5], in stainingbuffer/solution to stain the cells for cell cycle analysis[6]

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H341

Hazard Classifications

Muta. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
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    Certificates of Analysis (COA)

    Lot/Batch Number
    WXBF5497V
    WXBF4936V
    WXBF3263V
    WXBF4080V
    WXBF3567V

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    Haiying Liu et al.
    Frontiers in cell and developmental biology, 9, 684857-684857 (2021-10-05)
    It has been reported that calpain/caspase-mediated apoptosis induced by endoplasmic reticulum stress (ERS) in hepatic stellate cells (HSCs) by previous studies. At present, the activation of HSC is an important cause of liver fibrosis, and the induction of HSC apoptosis
    Aswathy Shailaja et al.
    Biofilm, 4, 100090-100090 (2022-11-18)
    Filamentous fungi are ubiquitous and frequent components of biofilms. A means to visualize them and quantify their viability is essential for understanding their development and disruption. However, quantifying filamentous fungal biofilms poses challenges because, unlike yeasts and bacteria, they are
    Robin Kumar et al.
    Methods in molecular biology (Clifton, N.J.), 2279, 213-223 (2021-03-09)
    Annexin V and propidium iodide staining is widely used for determining the cellular death through apoptosis. In the presence of Ca2+ ions, annexin V has a strong binding affinity for phosphatidylserine, a membrane phospholipid that during apoptosis is translocated from
    Julia Burrill et al.
    Forensic science international. Genetics, 46, 102269-102269 (2020-03-11)
    Forensic DNA typing from touched or handled items in routine casework is increasing as the sensitivity of detection techniques improves. Our understanding of the cellular/acellular content of touch deposits and the origins of the DNA therein is still limited. This
    Wei Liang et al.
    Molecular immunology, 112, 312-321 (2019-06-24)
    Precise glycosylation plays a crucial and distinctive role in thymic T cell development. The core fucosylation is dramatically up-regulated at the transition from CD4-CD8- (DN) to CD4+CD8+ (DP) in the thymic development. Ablation of core fucosylation in T cells did
    View All Related Papers

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    Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.

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