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安全信息

M4939

Sigma-Aldrich

髓鞘少突胶质细胞糖蛋白肽片段35-55

≥97% (HPLC)

别名:

MOG肽35-55,大鼠,小鼠

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About This Item

MDL编号:
UNSPSC代码:
12352209
NACRES:
NA.26

产品名称

髓鞘少突胶质细胞糖蛋白肽片段35-55, immunodominant epitope of MOG

质量水平

方案

≥97% (HPLC)

表单

powder

颜色

white

UniProt登记号

应用

cell analysis

储存温度

−20°C

基因信息

mouse ... Mog(17441)
rat ... Mog(24558)

Amino Acid Sequence

Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys

一般描述

髓鞘少突胶质细胞糖蛋白(MOG)是中枢神经系统的组成部分,存在于少突胶质细胞和髓鞘的表面。它的细胞外结构域被广泛用于创建多发性硬化的自身免疫动物模型。在大鼠中,MOG表达于海马体中。

应用


  • 红细胞生成素及其非红细胞生成素衍生物的延迟给药减轻鼠类慢性自身免疫性脑脊髓炎。: 该论文考察了红细胞生成素及其衍生物在自身免疫性脑脊髓炎治疗中的延迟治疗给药(Savino et al., 2006

  • 5-羟色胺再摄取的缺乏影响小鼠EAE中临床自身免疫性疾病的易感性和神经抗原特异性干扰素-γ的生成。: 该研究采用髓鞘少突胶质细胞糖蛋白35-55 片段来诱导小鼠中实验性自身免疫性脑脊髓炎,探索了5-羟色胺再摄取在调节免疫反应和自身免疫性疾病易感性的作用(Hofstetter et al., 2005)。

  • 以组蛋白去乙酰化酶抑制剂曲古抑菌素A进行的转录治疗减轻实验性自身免疫性脑脊髓炎。: 该研究证实了组蛋白去乙酰化酶抑制剂曲古抑菌素A在治疗实验性自身免疫性脑脊髓炎方面的有效性。研究人员采用髓鞘少突胶质细胞糖蛋白35-55 片段来诱导大鼠和小鼠疾病模型,提供了有关潜在表观遗传治疗的见解(Camelo et al., 2005)。

生化/生理作用

诱导啮齿动物的实验性自身免疫性脑脊髓炎模型;单次注射这种肽,可产生复发-缓解型神经系统疾病,表现出大量斑块状脱髓鞘病症;免疫接种MOG(35-55),能抑制MPTP损伤的多巴胺能神经元的自发再生功能。

其他说明

从0.1%TFA水溶液中冻干

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the difference between peptide content and purity of Product No. M4939?

    If a given lot of Product No. M4939 has, say, a peptide content of 85% and purity of 99%, this means that 85% of the vial content is the peptide, the remaining being water and trifluoroacetate salts. Of the 85% that is the peptide, 99% is Myelin oligodendroctye glycoprotein peptide fragment (35-55).

  6. For how long is a solution of this peptide (Product No. M4939) stable?

    Sigma-Aldrich has not performed any solution stability studies on M4939, so we do not have information as to whether solutions are stable refrigerated or frozen.

  7. What can I use to dissolve this peptide (Product No. M4939)?

    Every lot is tested for solubility at a concentration of 1 mg/mL, using either 1% acetic acid or water, resulting in a clear, colorless solution. The peptide is also soluble in an aqueous buffer such as 0.01 M PBS, pH 7.4, but we do not know whether it is equally as soluble in these buffers as it is in dilute acetic acid or water.

  8. Can I combine this peptide (Product No. M4939) with an adjuvant to prepare an immunizing emulsion?

    Unfortunately, we have no data based on our own studies or on literature references on Product No. M4939 to answer this question.

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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