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Merck
CN

PHR2209

Supelco

姜黄素

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

(E,E)-1,7-双(4-羟基-3-甲氧基苯基)-1,6-庚二烯-3,5-二酮, 二阿魏酸甲烷, 天然黄3

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About This Item

线性分子式:
[HOC6H3(OCH3)CH=CHCO]2CH2
CAS号:
分子量:
368.38
颜色索引号:
75300
Beilstein:
2306965
MDL编号:
UNSPSC代码:
41116107
NACRES:
NA.24

等级

certified reference material
pharmaceutical secondary standard

质量水平

Agency

traceable to USP 1151855

蒸汽密度

13 (vs air)

API类

curcumin

表单

solid

CofA

current certificate can be downloaded

包装

pkg of 50 mg

应用

pharmaceutical small molecule

储存温度

-10 to -25°C

SMILES字符串

COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O

InChI

1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+

InChI key

VFLDPWHFBUODDF-FCXRPNKRSA-N

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一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

应用

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

一种天然酚类化合物。它是有效的抗肿瘤剂,具有抗炎和抗氧化活性。除了具有化疗活性外,姜黄素还被认为是潜在的化学预防剂。它能够诱导癌细胞凋亡并抑制佛波酯诱导的蛋白激酶C(PKC)活性。据报道,它能抑制外周血单核细胞和肺泡巨噬细胞产生炎性细胞因子。它是EGFR酪氨酸激酶和IκB激酶的有效抑制剂。它能抑制诱导型一氧化氮合酶(iNOS)、环加氧酶和脂氧合酶。它易于渗透到细胞质中,在质膜、内质网和核膜等膜结构中积累。
它是一种天然酚类化合物,是姜黄的黄色来源。它是有效的抗肿瘤剂,作用于高度多样化的肿瘤特异性通路。它具有抗炎和抗氧化活性。它能够诱导癌细胞凋亡并抑制佛波酯诱导的蛋白激酶C(PKC)活性。据报道,它能抑制外周血单核细胞和肺泡巨噬细胞产生炎性细胞因子。它是EGFR酪氨酸激酶和IκB激酶的有效抑制剂。它能抑制诱导型一氧化氮合酶(iNOS)、环加氧酶(COX-2)和5-脂氧合酶(5-LOX)。

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAC3389 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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