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P7295

Supelco

Primidone

analytical standard

Synonym(s):

2-Desoxyphenobarbital, 5-Ethyl-5-phenylhexahydropyrimidine-4,6-dione

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About This Item

Empirical Formula (Hill Notation):
C12H14N2O2
CAS Number:
125-33-7
Molecular Weight:
218.25
EC Number:
204-737-0
MDL number:
MFCD00038662
UNSPSC Code:
41116107
PubChem Substance ID:
329820263
NACRES:
NA.24

grade

analytical standard

Quality Level

100

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

CCC1(C(=O)NCNC1=O)c2ccccc2

InChI

1S/C12H14N2O2/c1-2-12(9-6-4-3-5-7-9)10(15)13-8-14-11(12)16/h3-7H,2,8H2,1H3,(H,13,15)(H,14,16)

InChI key

DQMZLTXERSFNPB-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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General description

Primidone is a commonly used antiepileptic and anticonvulsant drug belonging to the class of barbiturates. It is found to be effective in the treatment of partial and generalized seizures.

Application

Primidone may be used as a reference standard for the determination of the analyte in serum samples using high-pressure liquid chromatography.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Anticonvulsant

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302,H351,H361d

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Repr. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

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A comparison of the teratogenic activity of the antiepileptic drugs carbamazepine, clonazepam, ethosuximide, phenobarbital, phenytoin, and primidone in mice.
Sullivan MF and McElhatton RP
Toxicology and Applied Pharmacology, 40(2), 365-378 (2006)
Simultaneous measurement of phenobarbital, phenytoin, primidone, ethosuximide, and carbamazepine in serum by high-pressure liquid chromatography.
Kabra MP, et al.
Clinical Chemistry, 23(7), 1284-1288 (1977)
Günther Deuschl et al.
The Lancet. Neurology, 10(2), 148-161 (2011-01-25)
Essential tremor is a common movement disorder. Tremor severity and handicap vary widely, but most patients with essential tremor do not receive a diagnosis and hence are never treated. Furthermore, many patients abandon treatment because of side-effects or poor efficacy.
Siyuan Zhao et al.
eLife, 9 (2020-04-29)
Transient Receptor Potential Melastatin 3 (TRPM3) is a Ca2+ permeable non-selective cation channel activated by heat and chemical agonists such as pregnenolone sulfate and CIM0216. TRPM3 mutations in humans were recently reported to be associated with intellectual disability and epilepsy;
Feng Chen et al.
Environmental pollution (Barking, Essex : 1987), 159(6), 1490-1498 (2011-04-12)
This study investigated the occurrence of 43 emerging contaminants including 9 endocrine-disrupting chemicals and 34 pharmaceuticals in three sites in Hebei Province, north China. Each site has a wastewater irrigated plot and a separate groundwater irrigated plot for comparison purpose.
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