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Safety Information

P-075

Supelco

Primidone solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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Empirical Formula (Hill Notation):
C12H14N2O2
CAS Number:
125-33-7
Molecular Weight:
218.25
EC Number:
200-659-6
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

SMILES string

CCC1(C(=O)NCNC1=O)c2ccccc2

InChI

1S/C12H14N2O2/c1-2-12(9-6-4-3-5-7-9)10(15)13-8-14-11(12)16/h3-7H,2,8H2,1H3,(H,13,15)(H,14,16)

InChI key

DQMZLTXERSFNPB-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

Related Categories

General description

Primidone, marketed as the barbiturate Mysoline®, Prysoline, or Liskantin®, is an anticonvulsant used in the treatment of partial and generalized seizures. This Certified Spiking Solution® is suitable for use in LC/MS or GC/MS applications in clinical toxicology or therapeutic drug monitoring to ensure patients remain within the drug′s therapeutic range.

Application


  • LC-MS/MS-Based Quantification of 9 Antiepileptic Drugs From a Dried Sample Spot Device.: This study utilizes PrimiDonesolution as a reagent in the development of a high-throughput method for quantifying antiepileptic drugs. PrimiDone is critical for accurate measurements in biochemical and pharmacological research, especially in epilepsy studies (DUrso et al., 2019).

  • Application of packed column supercritical fluid chromatography to the simultaneous determination of seven anticonvulsant drugs.: The research demonstrates the use of PrimiDonesolution in supercritical fluid chromatography to simultaneously determine multiple anticonvulsants, highlighting its importance as a stable reagent for laboratory use and anticonvulsant research (Bhoir et al., 1999).

  • The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. I. The influence of administration vehicles.: This paper discusses the use of PrimiDonesolution as a vehicle in laboratory evaluations of anticonvulsant drugs, emphasizing its stability and reliability for pharmacological experimentation and neurological disorder research (Loscher et al., 1990).

  • Simple GLC analysis of anticonvulsant drugs in commercial dosage forms.: This study utilizes PrimiDonesolution in gas-liquid chromatography to analyze commercial anticonvulsant drugs, underlining its role as a high-purity reagent for biochemical studies and anticonvulsant research (Watson et al., 1978).

  • Rapid micromethod for measuring anticonvulsant drugs in serum by high-performance liquid chromatography.: PrimiDonesolution is used in a rapid micromethod for serum analysis of anticonvulsants, demonstrating its utility as a PrimiDone reagent for anticonvulsant research and in vitro biochemical studies (Soldin and Hill, 1976).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Liskantin is a registered trademark of Desitin Arzneimittel GmbH
Mysoline is a registered trademark of Valeant Pharmaceuticals North America LLC
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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B-041

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P-004

Phenobarbital-D5 (side chain) solution, (deuterium label on side chain), 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

P-017

Phenobarbital-D5 (side chain) solution, (deuterium label on side chain), 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

P-018

Phenobarbital-D5 (ring) solution, (deuterium label on ring), 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

P-019

Phenobarbital-D5 (ring) solution, (deuterium label on ring), 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

P-138

Primidone-D5 solution, 100 μg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant®

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

WGK

WGK 2

Flash Point(F)

closed cup

Flash Point(C)

closed cup

Regulatory Information

危险化学品

Certificates of Analysis (COA)

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Günther Deuschl et al.
The Lancet. Neurology, 10(2), 148-161 (2011-01-25)
Essential tremor is a common movement disorder. Tremor severity and handicap vary widely, but most patients with essential tremor do not receive a diagnosis and hence are never treated. Furthermore, many patients abandon treatment because of side-effects or poor efficacy.
Feng Chen et al.
Environmental pollution (Barking, Essex : 1987), 159(6), 1490-1498 (2011-04-12)
This study investigated the occurrence of 43 emerging contaminants including 9 endocrine-disrupting chemicals and 34 pharmaceuticals in three sites in Hebei Province, north China. Each site has a wastewater irrigated plot and a separate groundwater irrigated plot for comparison purpose.
Christopher G Favilla et al.
Parkinsonism & related disorders, 19(2), 171-175 (2012-10-16)
Many essential tremor patients continue to require tremor suppressing medications following deep brain stimulation. The true incidence of medication usage in the years following surgery remains unclear, and the use of medications has not been included in the post-operative analyses
Susheela Rani et al.
Journal of separation science, 35(3), 359-366 (2012-01-20)
A method for the simultaneous determination of the antiepileptic drugs, phenobarbital (PHB), phenytoin (PTN), carbamazepine (CBZ), primidone (PRM) and oxcarbazepine (OXC) in human plasma and urine samples by using micro-extraction in a packed syringe as the sample preparation method connected
B Rezaei et al.
Talanta, 79(3), 669-675 (2009-07-07)
Application of electrospray ionization ion mobility spectrometry (ESI-IMS) as the detection technique for separation method based on molecular imprinted polymer (MIP) was investigated and evaluated. The method is exhaustively validated, including sensitivity, selectivity, recovery, reproducibility, and column capacity. The linear
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