All Photos(2)
11,12-Didehydro-γ-oxodibenz[b,f]azocine-5(6H)-butanoic acid (ACI), Dibenz[b,f]azocine-5(6H)-butanoic acid, 11,12-didehydro-γ-oxo- (ACI)
C19H15NO3
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Quality Level
Assay
≥95%
form
powder or crystals
color
white to off-white
mp
163-164 °C
storage temp.
−20°C
SMILES string
OC(CCC(N1CC2=CC=CC=C2C#CC3=CC=CC=C13)=O)=O
InChI
InChI=1S/C19H15NO3/c21-18(11-12-19(22)23)20-13-16-7-2-1-5-14(16)9-10-15-6-3-4-8-17(15)20/h1-8H,11-13H2,(H,22,23)
Application
DBCO Acid is a bifunctional building block comprising of an acid terminus useful for reaction with amine containing linkers in presence of activators such as EDC or HATU and a dibenzocyclooctyne (DBCO) terminus useful for copper-free click chemistry.
Features and Benefits
DBCO compounds react with azides without need of Cu(I) catalyst due to the strained nature of alkyne resulting in formation of fast and stable triazole linkage.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Copper-free click chemistry in living animals
Proceedings of the National Academy of Sciences of the USA, 107, 1821-1826 (2010)
A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes
Angewandte Chemie (International ed. in English), 41, 2596-2599 (2002)
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