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应用
氢化可的松已被用作少突胶质细胞、结肠细胞和上皮细胞培养基的补充剂。。
生化/生理作用
氢化可的松（也称为皮质醇）是由肾上腺分泌的一种内源性糖皮质激素。它由下丘脑-垂体-肾上腺（HPA）轴产生。氢化可的松能够糖皮质激素受体相互作用，并调节各种信号通路。它与能量调动的诱导、脑灌注率的增加和局部葡萄糖消耗有关。此外，这一物质还与心血管输出量和呼吸的增加、血液的重新分配、大脑和肌肉中分子和能量输送以及免疫反应的调节有关。
肾上腺皮质分泌的原始糖皮质激素。
肾上腺皮质分泌的原始糖皮质激素。它的抗炎效力是皮质酮的三倍，但 Na2+ 保留效力要低得多。
外形
室温粉末；按照工作液量分装后冻存，避免反复冻融
重悬
如需制备50μg/ml的储备溶液，可向1.0 mg产品中加入1 ml无水乙醇，轻轻晃动使其溶解，加入19 ml无菌培养基。
警示用语：
Danger
危险声明
危险分类
Repr. 1A - STOT RE 2
靶器官
Adrenal gland,Bone marrow
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
监管及禁止进口产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Immunomodulation in septic shock: hydrocortisone differentially regulates cytokine responses.
Briegel J et al.
Journal of the American Society of Nephrology, 12, S70-S70 (2001)
The cortisol awakening response (CAR): facts and future directions.
Fries E et al.
International Journal of Psychophysiology, 72, 67-67 (2009)
Human colon tissue in organ culture: preservation of normal and neoplastic characteristics.
Dame MK et al.
In Vitro Cellular & Developmental Biology. Animal, 46, 114-114 (2010)
Marc Hafner et al.
Cell chemical biology, 26(8), 1067-1080 (2019-06-11)
The target profiles of many drugs are established early in their development and are not systematically revisited at the time of FDA approval. Thus, it is often unclear whether therapeutics with the same nominal targets but different chemical structures are
A J Kent et al.
Biomaterials, 218, 119337-119337 (2019-07-22)
Laminin-111 (Ln-1), an extracellular matrix (ECM) glycoprotein found in the basement membrane of mammary gland epithelia, is essential for lactation. In mammary epithelial cells (MECs), dystroglycan (Dg) is believed to be necessary for polymerization of laminin-111 into networks., thus we
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