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762040

二苄环辛基-磺基-N-羟基琥珀酰亚胺酯

Name: 二苄环辛基-磺基-N-羟基琥珀酰亚胺酯
Brand: ALDRICH

for Copper-free Click Chemistry

别名:

DBCO-磺基-NHS 酯, DBCO-磺基-SE

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About This Item

经验公式（希尔记法）:

C₂₅H₂₁N₂NaO₈S

分子量:

532.50

MDL编号:

MFCD22572669

UNSPSC代码:

12352108

PubChem化学物质编号:

329766600

NACRES:

NA.22

质量水平

100

形式

solid

反应适用性

reaction type: click chemistry
reagent type: linker

mp

240-260 °C

储存温度

−20°C

SMILES字符串

O=C(CCCCC(ON(C(CC1S(=O)(O[Na])=O)=O)C1=O)=O)N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4

InChI

1S/C25H22N2O8S.Na/c28-22(11-5-6-12-24(30)35-27-23(29)15-21(25(27)31)36(32,33)34)26-16-19-9-2-1-7-17(19)13-14-18-8-3-4-10-20(18)26;/h1-4,7-10,21H,5-6,11-12,15-16H2,(H,32,33,34);/q;+1/p-1

InChI key

QXKHPYSXPCJSPR-UHFFFAOYSA-M

应用

水溶性琥珀酰亚胺酯/NHS 功能化环辛炔衍生物，用于将环辛炔基团掺入含胺化合物或生物分子。环辛烯在促进无铜叠氮炔环加成反应中是有用的。这种二苯并环辛炔将与叠氮官能化化合物或生物分子反应，而不需要 Cu (I) 催化剂产生稳定的三唑键。

在合成刺激响应 DNA 门控 (NMOF) 过程中，二苯并环辛基磺酸 N-羟基琥珀酰亚胺酯可用于通过点击化学使用核酸对纳米金属有机框架 (NMOF) 进行共价修饰。这些 NMOF 可以作为荧光剂或抗癌药的载体，使其在靶向释药系统中非常有用。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Profiling of Exosomal Biomarkers for Accurate Cancer Identification: Combining DNA-PAINT with Machine- Learning-Based Classification.

Chen Chen et al.

Small (Weinheim an der Bergstrasse, Germany), 15(43), e1901014-e1901014 (2019-09-04)

Exosomes are endosome-derived vesicles enriched in body fluids such as urine, blood, and saliva. So far, they have been recognized as potential biomarkers for cancer diagnostics. However, the present single-variate analysis of exosomes has greatly limited the accuracy and specificity

Instructing cells with programmable peptide DNA hybrids.

Freeman R, et al.

Nature Communications, 8 (2017)

DNA quadruplexes as molecular scaffolds for controlled assembly of fluorogens with aggregation-induced emission.

Longyi Zhu et al.

Chemical science, 9(9), 2559-2566 (2018-05-08)

Aggregation-induced emission (AIE) can be generated due to the restriction of intramolecular motions. The controllable assembly of fluorogens with AIE properties (AIEgens) is able to provide a new opportunity for precise manipulation of fluorescent signal transduction. Here, a tetrapod DNA

Tethering Growth Factors to Collagen Surfaces Using Copper-free Click Chemistry: Surface Characterization and In Vitro Biological Response.

Lee HJ, et al.

ACS Applied Materials & Interfaces, 9(28), 23389-23399 (2017)

Optically Transparent Dense Colloidal Gels.

Zupkauskas M, et al.

Chemical Science (2017)

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