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Merck
CN

761524

二苯并环辛炔-N-羟基琥珀酰亚胺酯

for Copper-free Click Chemistry

别名:

DBCO-NHS酯, DBCO-SE

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关于此项目

经验公式（希尔记法）:
C23H18N2O5
分子量:
402.40
NACRES:
NA.22
PubChem Substance ID:
329766555
UNSPSC Code:
12352108
MDL number:
MFCD24386367

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产品名称

二苯并环辛炔-N-羟基琥珀酰亚胺酯, for Copper-free Click Chemistry

InChI

1S/C23H18N2O5/c26-20(13-14-23(29)30-25-21(27)11-12-22(25)28)24-15-18-7-2-1-5-16(18)9-10-17-6-3-4-8-19(17)24/h1-8H,11-15H2

SMILES string

O=C(CCC(ON(C(CC1)=O)C1=O)=O)N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4

InChI key

XCEBOJWFQSQZKR-UHFFFAOYSA-N

form

solid

reaction suitability

reaction type: click chemistry
reagent type: cross-linking reagent

mp

149-157 (decomposition)

functional group

NHS ester

storage temp.

−20°C

Quality Level

100

相关类别

Application

二苯并环辛炔- N -羟基琥珀酰亚胺酯常用于：
  • 通过将DBCO基团引入其表面进行抗体和链霉亲和素等生物分子的修饰和标记
  • 作为交联剂使抗原在聚乳酸-乙醇酸共聚物（PLGA）的表面结合。

General description

DBCO-NHS 酯常用于生物偶联。它由NHS酯组成，NHS酯可以与生物分子上的伯胺和炔基反应，该炔基导致与含叠氮化物分子的特异性反应。该反应通过一种称为应变促进炔烃-叠氮化物环加成的无铜点击化学过程进行。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKDB0017
MKCZ5722
MKCZ2625
MKCX9977
MKCX5454

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Copper-Free Click Chemistry

Copper-free click chemistry is an alternative approach to click chemistry that proceeds at a lower activation barrier and is free of cytotoxic transition metal catalysts.

无铜点击化学

无铜点击化学是点击化学的一种替代方法，可在较低的活化屏障下进行，且没有细胞毒性过渡金属催化剂。

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