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Merck
CN
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文件

安全信息

H0135

Sigma-Aldrich

氢化可的松

γ-irradiated, powder, BioXtra, suitable for cell culture

别名:

11β,17α,21-三羟基孕酮-4-烯-3,20-二酮, 17-羟基皮质酮标准液, 4-孕烯-11β,17α,21-三醇-3,20-二酮, 皮质醇标准液, 肯德尔氏化合物F, 赖希斯坦氏物质M

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About This Item

经验公式（希尔记法）:
C21H30O5
CAS号:
50-23-7
分子量:
362.46
Beilstein:
1354819
EC 号:
200-020-1
MDL编号:
MFCD00011654
UNSPSC代码:
12352209
PubChem化学物质编号:
24895394
NACRES:
NA.77

生物来源

synthetic (organic)

质量水平

200

无菌性

γ-irradiated

产品线

BioXtra

检测方案

≥80% (HPLC)

形式

powder

技术

cell culture | mammalian: suitable

mp

211-214 °C (lit.)

溶解性

ethanol: 1 mg/mL, clear

运输

ambient

储存温度

room temp

SMILES字符串

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key

JYGXADMDTFJGBT-VWUMJDOOSA-N

基因信息

human ... ABCB1(5243) , CYP3A4(1576) , NR3C1(2908) , SERPINA6(866)
mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126)
rat ... Ar(24208) , Nr3c1(24413)

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相关类别

一般描述

用于上皮和内皮贴壁细胞培养的氢化可的松。

应用

氢化可的松可用于以下应用：
  • 用于肌原性的诱导和鉴定
  • 用于长期基质培养和甲基纤维素培养（作为培养基中的成分之一）
  • 用于成脂分化（作为成脂培养基中的成分之一）
  • 用于细胞培养：将人乳腺上皮细胞MCF-10A细胞保存在补充有氢化可的松及其他成分的DMEM/F12中
  • SUM149细胞系是从原始IBC建立的，并在补充有FBS的含胰岛素和氢化可的松的Ham′s F12培养基中进行生长
  • 可用于黑色素瘤球状细胞的分化测定中

生化/生理作用

肾上腺皮质分泌的原始糖皮质激素。它的抗炎效力是皮质酮的三倍，但 Na2+ 保留效力要低得多。

外形

室温下为粉末状；分成小份冻存，以避免使用时反复冷冻/解冻

重悬

要制备 50μg/mL 的储存液，可加入 1mL 无水乙醇，温和搅拌使之溶解，在搅拌下加入 19mL 无菌培养基。

相关产品

产品编号
说明
价格

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H360Df,H373

危险分类

Repr. 1A - STOT RE 2

靶器官

Adrenal gland,Bone marrow

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

监管及禁止进口产品

分析证书(COA)

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